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Journal / Neuroscience / Lateral Fluid Percussion: Model of Traumatic…
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Neuroscience

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JoVE Journal Neuroscience
Lateral Fluid Percussion
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Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice

Article DOI: 10.3791/3063-v • 11:05 min • August 22nd, 2011
August 22nd, 2011 •
1, 1, 2,3, 1, 1
1Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 2Spinal Cord and Brain Injury Research Center, 3Department of Anatomy and Neurobiology, Department of Physical Medicine and Rehabilitation, University of Kentucky Chandler Medical Center

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Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.

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Lateral Fluid Percussion Traumatic Brain Injury TBI Research Head Injuries Morbidity Mortality Primary Injury Secondary Consequences Regenerative Processes Contusion Skull Fracture Shearing Stretching Displacement Of Brain Hematomas Lacerations Vascular Response White Matter Damage Diffuse Axonal Injury Edema Increased Intracranial Pressure Microscopic Alterations Excitotoxic Neurotransmitters Immune Mediators Oxygen Radicals Long-term Neurological Disabilities Animal Models Of TBI Cellular Events Molecular Events
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