Name: Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools (Video) | JoVE Journal
Uploaded: 2007-10-01T12:55:13.000+00:00
Duration: 16 min 5 s
Description: Explore MEMS-based diagnostic tools for global health using microfluidic chips to capture rare cells from small blood samples. This bioengineering method enables low-cost, rapid disease detection in resource-limited settings worldwide.

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using micro-electro-mechanical systems (mems) to develop diagnostic tools

Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

I'm U De Mercy, I'm the principal investigator of Bio Stick MAMs in Medicine Labs. I did my PhD at Stanford University in electrical engineering. I did a postdoc at Harvard Medical School at MGH working on bio acoustic MAMs or mostly bio MAs.And now I'm continuing as a faculty at Harvard Medical School at Harvard MIT Health Sciences and Technology. And continuing with my research that I enjoy very much. The work that I did during my PhD was very much related to droplets and using acoustics to generate precise size droplets and control their location and position to deposit very sensitive polymers.Now we apply similar technologies to encapsulate cells in droplets and then position them on the surfaces for various applications in tissue engineering to print cells on the surfaces to pattern cells. Also, there are applications where you want to see that you can encapsulate few cells or a single cell or from the same population and to see the differences between the same population from one cell to another there being able to encapsulate cells in droplets at high throughput rates like 10, 000 cells per second kind of rates becomes very important and very useful to understand biological

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Research

JoVE Journal

Biology

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A Novel Method for In Situ Electromechanical Characterization of Nanoscale Specimens

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Design and Characterization Methodology for Efficient Wide Range Tunable MEMS Filters

New tools for mechanobiology research are needed to understand how mechanical stress activates biochemical pathways and elicits biological responses. Here, we showcase a new method for selective mechanical stimulation of immobilized animals with a microfluidic trap allowing high-resolution imaging of cellular responses.

Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans

Microfluidics is a powerful tool for the development of diagnostic tests. However, expensive equipment and materials, as well as laborious fabrication and handling techniques, are often required. Here, we detail the fabrication protocol of an acrylic microfluidic device for magnetic micro- and nanoparticle-based immunoassays in a low-cost and simple-to-use setting.

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

This protocol presents the configuration of a compression test device capable of precisely measuring the mechanical properties of microstructures in the small-strain region, along with a systematic method for compression testing using this device. The proposed device can be used to analyze various microstructures and the mechanical behavior of polymer-based materials.

Measurement of Compressive Stress-Strain Response at Small-Strains

Explore MEMS-based diagnostic tools for global health using microfluidic chips to capture rare cells from small blood samples. This bioengineering method enables low-cost, rapid disease detection in resource-limited settings worldwide.

Using Micro-Electro-Mechanical Systems (MEMS) to Develop Diagnostic Tools

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