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JoVE Journal Neuroscience
Beoordeling van langdurige depressie inductie in volwassen cerebellaire schijfjes
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Beoordeling van langdurige depressie inductie in volwassen cerebellaire schijfjes

Article DOI: 10.3791/59859-v • 09:30 min • October 16th, 2019
October 16th, 2019 •
1, 2
1Laboratory for Behavioral Genetics, Center for Brain Science, RIKEN, 2Senior Adviser's Office, Center for Brain Science, RIKEN

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In sommige genen gemanipuleerd dieren, met behulp van een enkel protocol kan falen om te induceren LTD in cerebellaire Purkinje cellen, en er kan een discrepantie tussen LTD en motorische leren. Er zijn meerdere protocollen nodig om LTD-inductie in gengemanipuleerde dieren te beoordelen. Standaardprotocollen worden weergegeven.

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Neurowetenschappen uitgave 152 synaptische plasticiteit LTD brain slice gehele cel opname muis Purkinje Cell cerebellum parallelle Fiber klimmen Fiber
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