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JoVE Journal Genetics
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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Article DOI: 10.3791/60215-v • 09:40 min • October 4th, 2019
October 4th, 2019 •
1, 1
1Department of Neurosurgery, Brigham and Women's Hospital-Harvard Medical School

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Described here is a protocol for characterizing modules of biologically synergistic miRNAs and their assembly into short transgenes, which allows simultaneous overexpression for gene therapy applications.

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MiRNAs Glioblastoma Engineering Artificial Clusters Gene Therapy Modulation Eukaryotic Cells Molecular Cloning Micro RNA Functional Interactions Therapy Brain Cancer Alterations Of Gene Expression Bioinformatics Trans Genes Breast Cancer Thyroid Cancer TRK-11 Micro RNA Processing DNA Clusters
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