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Immunology and Infection

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JoVE Journal Immunology and Infection
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Article DOI: 10.3791/63127-v • 08:41 min • November 5th, 2021
November 5th, 2021 •
1, 1, 1, 1, 1, 1
1Texas Biomedical Research Institute

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Summary
Automatic Translation

This protocol describes the dynamics of viral infections using luciferase- and fluorescence-expressing recombinant (r)SARS-CoV-2 and an in vivo imaging systems (IVIS) in K18 hACE2 transgenic mice to overcome the need of secondary approaches required to study SARS-CoV-2 infections in vivo.

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Live Imaging Quantification Viral Infection K18 HACE2 Transgenic Mice Reporter-expressing Recombinant SARS-CoV-2 Viral Detection Viral Tracking In Vivo Imaging Ex Vivo Studies Therapeutics Pathogenicity Viral Replication Trophism Luciferase Expressing SARS-CoV-2 Bioluminescence Monitoring In Vivo Imaging System IVIS Exposure Time
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