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Immunology and Infection

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JoVE Journal Immunology and Infection
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Article DOI: 10.3791/63499-v • 05:08 min • March 1st, 2022
March 1st, 2022 •
*1, *1, *1, 2, 1
1Department of Internal Medicine, the University of Texas Medical Branch, 2Department of Pathology, the University of Texas Medical Branch
* These authors contributed equally

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Summary
Automatic Translation

The present protocol describes the development of a Crohn's-like colitis model in rodents. Transmural inflammation leads to stenosis at the TNBS instillation site, and mechanical enlargement is observed in the segment proximal to the stenosis. These changes allow studying mechanical stress in colitis.

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TNBS-induced Rodent Model Crohn's Disease Mechanical Stress Transmural Inflammation Stenotic Crohn's Disease Comparative Study Crohn's Colitis Inflammation Site Mechanical Distention Anesthesia Table Colitis Induction Polyurethane Catheter Saline Administration Rat Abdomen Surgical-grade Scissors Forceps
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