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JoVE Journal Neuroscience
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

Article DOI: 10.3791/64286-v • 07:13 min • February 10th, 2023
February 10th, 2023 •
1, 1, 1,2
1Department of Audiology and Speech-Language Pathology, MacKay Medical College, 2Institute of Biomedical Sciences, MacKay Medical College

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Summary
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Here, we present a protocol for a mouse model of noise-induced hearing loss (NIHL). To induce NIHL, we developed a new and simple device using corrugated plastic, a rat trap cage, and a speaker. Auditory brainstem response and immunofluorescence imaging were employed to assess the hearing function and outer hair cell damage, respectively.

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Modified Experimental Conditions Noise-Induced Hearing Loss Mice Assessment Hearing Function Outer Hair Cell Damage Method Procedure ABR Animal Model Scientists Mechanism Treatment Strategies Dian-Shiue Lee Laboratory Rat Trap Cage Corrugated Plastic Boards Mesh Grid CLIO Application Software Speaker Icon TwoSin Frequency 1 Frequency 2 Sound Leq Tab
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