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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Article DOI: 10.3791/64535-v • 06:08 min • February 10th, 2023
February 10th, 2023 •
1,2,3,4,5, 1,2, 1,2, 6, 6, 1,2, 1,2, 6, 1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester

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Summary
Automatic Translation

Here, we describe a protocol in which an acute lymphoblastic leukemia patient-derived xenograft model is used as a strategy to assess and monitor CD19-targeted chimeric antigen receptor T cell-associated toxicities.

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Chimeric Antigen Receptor T Cell-Associated Toxicities Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model CAR-T Toxicities CART19 Administration Clinic Observations Platform Translatable Model Clinically Relevant Model Human T-cells Tumor Cells Assessment Treatment Strategies Wellbeing Changes Motor Weakness Hunched Body Loss Of Body Weight Peripheral Blood Analysis Serum Isolation Cytokines MRI Imaging Gadolinium Saline Solution Insulin Syringe
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