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JoVE Journal Neuroscience
Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
Journal (Neuroscience)
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
Setting up Pain Body Diagram for Pain Assessment (Video) | JoVE
Journal (Neuroscience)
Setting up Pain Body Diagram for Pain Assessment (Video) | JoVE
 

Open-Source Real-Time Closed-Loop Electrical Threshold Tracking for Translational Pain Research

Article DOI: 10.3791/64898-v • 10:28 min • April 21st, 2023
April 21st, 2023 •
1,2, 1, 3, 4, 1, 5, 1, 1
1Anaesthesia, Pain, and Critical Care Sciences, School of Physiology, Pharmacology, & Neuroscience, University of Bristol, 2Eli Lilly and Company, 3Department of Computer Science, University of Bristol, 4Department of Aerospace Engineering, University of Bristol, 5Research Computing, University of Bristol

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Summary
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APTrack is a software plugin developed for the Open Ephys platform that enables real-time data visualization and the closed-loop electrical threshold tracking of neuronal action potentials. We have successfully used this in microneurography for human C-fiber nociceptors and mouse C-fiber and Aδ-fiber nociceptors.

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Open-source Real-time Closed-loop Electrical Threshold Tracking Translational Pain Research Nociceptor Sensitization Chronic Pain Automated Excitability Translational Bridge Humans Animals Pathology Treatments Therapeutic Agent Biomarker Of Efficacy Electrophysiologists Time Loop Stimuli Optogenetics Experiment Management Software Demo Data Acquisition Board
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