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Journal / Bioengineering / Stress-induced Antibiotic Susceptibility Testing…
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JoVE Journal Bioengineering
Stress-induced Antibiotic Susceptibility Testing on a Chip
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Stress-induced Antibiotic Susceptibility Testing on a Chip

Article DOI: 10.3791/50828-v • 12:41 min • January 8th, 2014
January 8th, 2014 •
1, 1, 2, 1,3, 1,4
1Fraunhofer USA Center for Manufacturing Innovation, 2Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 3Department of Mechanical Engineering, Boston University, 4Department of Biomedical Engineering, Boston University

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Summary
Automatic Translation

We have developed a microfluidic platform for rapid antibiotic susceptibility testing. Fluid is passed at high speeds over bacteria immobilized on the bottom of a microfluidic channel. In the presence of stress and antibiotic, susceptible strains of bacteria die rapidly. However, resistant bacteria can survive these stressful conditions.

Tags

Microfluidic Method Antibiotic Susceptibility Testing Stress-induced Environment Bacteria Immobilization Stress Activation Biochemical Pathways Resistant Bacteria Susceptible Strains Standard Techniques Innovative Approaches Bacterial Culture Protocols Microfluidic Channels Cell Viability Monitoring Fluorescence Image Processing Culture Media Flow Mechanical Stress Application Enzymes Microarray Substrates Drug Development And Testing
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