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Biology

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Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
 

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Article DOI: 10.3791/50840-v 12:38 min December 18th, 2013
December 18th, 2013

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Summary

To study the relationship between protein homeostasis, stress and aging, we monitored changes in protein folding by following protein dysfunction, protein localization in the cell and protein stability at the organismal, cellular and protein levels, using the genetically tractable metazoan Caenorhabditis elegans as a model system.

Tags

Caenorhabditis Elegans Protein Homeostasis Multicellular Organism Protein Folding Protein Function Proteostasis Metabolism Development Aging Temperature-sensing Behavioral Assays Imaging Biochemical Approaches Protein Misfolding Protein Mislocalization Cellular Folding Capacity Protein Stability Protein Conformation
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