JoVE Journal
Medicine
Medicine
A subscription to JoVE is required to view this content.
Chapters
Summary
DNBS/TNBS induced colitis offers an alternative and inexpensive method to study the pathobiology of inflammatory bowel disease. The protocol discussed in this paper outlines the successful application of DNBS to induce colitis in mice and rats and allows one to thoroughly study host-mediated intestinal responses.