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JoVE Journal Bioengineering
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Article DOI: 10.3791/52735-v • 11:43 min • April 3rd, 2015
April 3rd, 2015 •
1, 2, 2,3
1Systems Biophysics Department, FOM Institute AMOLF, 2Mechanobiology Institute, National University of Singapore, 3Department of Biomedical Engineering, National University of Singapore

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Summary
Automatic Translation

The mechanical properties and microstructure of the extracellular matrix strongly affect 3D migration of cells. An in vitro method to study the spatiotemporal cell migration behavior in biophysically variable environments, at both population and individual cell levels, is described.

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Concentric Gel System Biophysical Role Matrix Microenvironment 3D Cell Migration Cell Migration Embryonic Development Wound Healing Tumor Metastasis Cancer Metastasis Biochemical Principles Biophysical Principles Three-dimensional Microenvironments In Vitro Assay Quantitative Examination Mechanosensing Ability Extracellular Matrix Collagen Gels Breast Cancer Cells MDA-MB-231 Model System Cell Population Spread Migration Dynamics Live-cell Imaging Spatiotemporally-resolved Data Biophysical Factors
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