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A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research

Article DOI: 10.3791/59679-v • 08:17 min • August 15th, 2019
August 15th, 2019 •
*1, *1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
1BeiGene (Beijing) Co., Ltd.
* These authors contributed equally

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Summary
Automatic Translation

We describe a human peripheral blood mononuclear cell (PBMC) — based humanized xenograft mouse model for translational immuno-oncology research. This protocol could serve as a general guideline for establishing and characterizing similar models for I-O therapy assessment.

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Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model Translational Immuno-oncology (I-O) Research Mouse Models Human Immunity Cancer Xenografts Myeloid Cell Depletion Cyclophosphamide Disulfiram NOD/SCID Female Mice Human Tumor Cell Line Cells PBS Plus 50% Metrogel Subcutaneously Primary Tumor Volume Optomic Scissors Patient-derived Xenografts
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