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Journal / Biochemistry / Interactions with and Membrane Permeabilization…
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Biochemistry
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JoVE Journal Biochemistry
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
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Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Article DOI: 10.3791/59883-v • 15:04 min • September 28th, 2019
September 28th, 2019 •
1, *1, *1, *1, *1, 1, 1
1Department of Biological Sciences, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan, 45137-66731, Iran
* These authors contributed equally

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Summary
Automatic Translation

Provided here is a protocol for investigating the interactions between native form, prefibrillar, and mature amyloid fibrils of different peptides and proteins with mitochondria isolated from different tissues and various areas of the brain.

Tags

Amyloid Toxicity Membrane Permeabilization Brain Mitochondria In Vitro Biological Model Amyloid Fibrils Alpha-synuclein Neurodegenerative Diseases Rat Brain Mitochondrial Properties Isolation Buffer Dounce Homogenizer
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