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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Article DOI: 10.3791/60991-v • 07:32 min • May 6th, 2020
May 6th, 2020 •
1, 1, 1, 1, 1, 1, 1,2, 1,3
1Center for Orthopedic Research and Translational Sciences, Department of Orthopedics and Rehabilitation, Pennsylvania State College of Medicine, 2Department of Biochemistry and Molecular Biology, Pennsylvania State College of Medicine, 3Department of Pharmacology, Pennsylvania State College of Medicine

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Summary
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The current protocol establishes a rigorous and reproducible method for quantification of morphological joint changes that accompany osteoarthritis. Application of this protocol can be valuable in monitoring disease progression and evaluating therapeutic interventions in osteoarthritis.

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Standardized Histomorphometric Evaluation Osteoarthritis Surgical Mouse Model Joint Changes Quantitative Analysis Reproducible Method Specific Treatments Therapeutic Efficacy Cartilage And Bone Quantification Musculoskeletal Research Training Sessions Microscope Camera Computer Touch Screen Monitor Software Program Slide Measurement Window Tibial Articular Surface Femoral Articular Surface Tibial Subchondral Bone
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