Tobias Madl Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry Medical University of Graz Biography Publications Institution JoVE Articles Tobias Madl has not added a biography. If you are Tobias Madl and would like to personalize this page please email our Author Liaison for assistance. Publications P53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR International Journal of Molecular Sciences. Oct, 2021 | Pubmed ID: 34768862 XIAP Restrains TNF-driven Intestinal Inflammation and Dysbiosis by Promoting Innate Immune Responses of Paneth and Dendritic Cells Science Immunology. 11, 2021 | Pubmed ID: 34739338 Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation Frontiers in Molecular Biosciences. 2021 | Pubmed ID: 34738012 Intracellular Drug Binding Affinities by NMR Acta Crystallographica. Section D, Structural Biology. Oct, 2021 | Pubmed ID: 34605425 Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients Nutrients. Sep, 2021 | Pubmed ID: 34578983 Reduced B12 Uptake and Increased Gastrointestinal Formate Are Associated with Archaeome-mediated Breath Methane Emission in Humans Microbiome. 09, 2021 | Pubmed ID: 34560884 Structural and DNA-binding Properties of the Cytoplasmic Domain of Vibrio Cholerae Transcription Factor ToxR The Journal of Biological Chemistry. 10, 2021 | Pubmed ID: 34487759 Metabolic Profiling Links Cardiovascular Risk and Vascular End Organ Damage Atherosclerosis. 08, 2021 | Pubmed ID: 34344526 Multiple Regulatory Intrinsically Disordered Motifs Control FOXO4 Transcription Factor Binding and Function Cell Reports. Jul, 2021 | Pubmed ID: 34320339 Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy ACS Sensors. 08, 2021 | Pubmed ID: 34282892 ATP Regulates RNA-driven Cold Inducible RNA Binding Protein Phase Separation Protein Science : a Publication of the Protein Society. 07, 2021 | Pubmed ID: 33991007 Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming Cancers. Apr, 2021 | Pubmed ID: 33924061 Potassium Ions Promote Hexokinase-II Dependent Glycolysis IScience. Apr, 2021 | Pubmed ID: 33870140 NLRP3 As a Sensor of Metabolism Gone Awry Current Opinion in Biotechnology. 04, 2021 | Pubmed ID: 33862489 Dietary Spermidine Improves Cognitive Function Cell Reports. 04, 2021 | Pubmed ID: 33852843 Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia International Journal of Molecular Sciences. Feb, 2021 | Pubmed ID: 33671212 Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2021 | Pubmed ID: 33646155 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition) Autophagy. Feb, 2021 | Pubmed ID: 33634751 Tissue-Specific Landscape of Metabolic Dysregulation During Ageing Biomolecules. 02, 2021 | Pubmed ID: 33562384 Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33450841 Imbalances in the Eye Lens Proteome Are Linked to Cataract Formation Nature Structural & Molecular Biology. 02, 2021 | Pubmed ID: 33432246 β-catenin Regulates FOXP2 Transcriptional Activity Via Multiple Binding Sites The FEBS Journal. 05, 2021 | Pubmed ID: 33284517 Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions Cell Reports. 12, 2020 | Pubmed ID: 33357437 Metabolic Reprogramming of Donor T Cells Enhances Graft-versus-leukemia Effects in Mice and Humans Science Translational Medicine. 10, 2020 | Pubmed ID: 33115954 Dipeptidyl Peptidase 3 Modulates the Renin-angiotensin System in Mice The Journal of Biological Chemistry. 10, 2020 | Pubmed ID: 32546481 Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner MSystems. Jun, 2020 | Pubmed ID: 32518196 Transgene Integration Causes RARB Downregulation in Homozygous Tg4-42 Mice Scientific Reports. 04, 2020 | Pubmed ID: 32286473 Nonclassical Nuclear Localization Signals Mediate Nuclear Import of CIRBP Proceedings of the National Academy of Sciences of the United States of America. 04, 2020 | Pubmed ID: 32234784 Probing Surfaces in Dynamic Protein Interactions Journal of Molecular Biology. 04, 2020 | Pubmed ID: 32135192 Structure of an RNA Aptamer in Complex with the Fluorophore Tetramethylrhodamine Nucleic Acids Research. 01, 2020 | Pubmed ID: 31754719 A Small Molecule Chaperone Rescues the Stability and Activity of a Cancer-associated Variant of NAD(P)H:quinone Oxidoreductase 1 In vitro FEBS Letters. 02, 2020 | Pubmed ID: 31605637 Cysteine Oxidation Triggers Amyloid Fibril Formation of the Tumor Suppressor P16 Redox Biology. 01, 2020 | Pubmed ID: 31539802 Low Cardiac Lipolysis Reduces Mitochondrial Fission and Prevents Lipotoxic Heart Dysfunction in Perilipin 5 Mutant Mice Cardiovascular Research. 02, 2020 | Pubmed ID: 31166588 Presenilin-1 Established ER-Ca Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells Upon Elevated Glucose Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 31529929 Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans Cell Metabolism. 09, 2019 | Pubmed ID: 31471173 NMR Characterization of Solvent Accessibility and Transient Structure in Intrinsically Disordered Proteins Journal of Biomolecular NMR. Jul, 2019 | Pubmed ID: 31297688 Endothelial Lipase Increases Antioxidative Capacity of High-density Lipoprotein Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 10, 2019 | Pubmed ID: 31220617 Acetyl-CoA Carboxylase 1-dependent Lipogenesis Promotes Autophagy Downstream of AMPK The Journal of Biological Chemistry. 08, 2019 | Pubmed ID: 31209110 Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate Are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients Scientific Reports. 05, 2019 | Pubmed ID: 31043697 Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex Journal of Molecular Biology. 06, 2019 | Pubmed ID: 31034892 Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease Circulation Research. Apr, 2019 | Pubmed ID: 30929571 The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation Via Chaperoning Elongation Factor 2 Molecular Cell. 04, 2019 | Pubmed ID: 30876805 PH-Lemon, a Fluorescent Protein-Based PH Reporter for Acidic Compartments ACS Sensors. 04, 2019 | Pubmed ID: 30864782 Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2019 | Pubmed ID: 30790505 A Single Alcohol Binge Impacts on Neutrophil Function Without Changes in Gut Barrier Function and Gut Microbiome Composition in Healthy Volunteers PloS One. 2019 | Pubmed ID: 30707717 N-acetylaspartate Pathway is Nutrient Responsive and Coordinates Lipid and Energy Metabolism in Brown Adipocytes Biochimica Et Biophysica Acta. Molecular Cell Research. 03, 2019 | Pubmed ID: 30595160 Enhanced Inter-compartmental Ca Flux Modulates Mitochondrial Metabolism and Apoptotic Threshold During Aging Redox Biology. 01, 2019 | Pubmed ID: 30458321 Oxidative Stress-induced Structural Changes in the Microtubule-associated Flavoenzyme Irc15p from Saccharomyces Cerevisiae Protein Science : a Publication of the Protein Society. 01, 2019 | Pubmed ID: 30267443 Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC Via DPP9 Inhibition in Cardiomyocytes Frontiers in Physiology. 2018 | Pubmed ID: 30487758 NMR Spectroscopy Enables Simultaneous Quantification of Carbohydrates for Diagnosis of Intestinal and Gastric Permeability Scientific Reports. 10, 2018 | Pubmed ID: 30279548 Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting Cell Metabolism. 11, 2018 | Pubmed ID: 30122555 The Neuronal S100B Protein is a Calcium-tuned Suppressor of Amyloid-β Aggregation Science Advances. 06, 2018 | Pubmed ID: 29963623 Acetate-free, Citrate-acidified Bicarbonate Dialysis Improves Serum Calcification Propensity-a Preliminary Study Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 11, 2018 | Pubmed ID: 29860419 Lysyl Oxidase-like Protein 2 (LOXL2) Modulates Barrier Function in Cholangiocytes in Cholestasis Journal of Hepatology. 08, 2018 | Pubmed ID: 29709678 Regulation of Cellular Senescence Via the FOXO4-p53 Axis FEBS Letters. 06, 2018 | Pubmed ID: 29683489 Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation Cell. 04, 2018 | Pubmed ID: 29677514 A Switch Point in the Molecular Chaperone Hsp90 Responding to Client Interaction Nature Communications. 04, 2018 | Pubmed ID: 29662162 Novel Genetically Encoded Fluorescent Probes Enable Real-time Detection of Potassium in Vitro and in Vivo Nature Communications. 11, 2017 | Pubmed ID: 29127288 Integrative Metabolomics As Emerging Tool to Study Autophagy Regulation Microbial Cell (Graz, Austria). Jul, 2017 | Pubmed ID: 28845422 Patchy Proteins Form a Perfect Lens Science (New York, N.Y.). 08, 2017 | Pubmed ID: 28798115 Characterization of Protein-Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements Journal of the American Chemical Society. 09, 2017 | Pubmed ID: 28780861 RNA Structure Refinement Using NMR Solvent Accessibility Data Scientific Reports. 07, 2017 | Pubmed ID: 28710477 Flexible IgE Epitope-containing Domains of Phl P 5 Cause High Allergenic Activity The Journal of Allergy and Clinical Immunology. 10, 2017 | Pubmed ID: 28532654 Transient Helicity in Intrinsically Disordered Axin-1 Studied by NMR Spectroscopy and Molecular Dynamics Simulations PloS One. 2017 | Pubmed ID: 28355271 Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging Cell. 03, 2017 | Pubmed ID: 28340339 The Redox Environment Triggers Conformational Changes and Aggregation of HIAPP in Type II Diabetes Scientific Reports. 03, 2017 | Pubmed ID: 28287098 Allosteric Modulation of Peroxisomal Membrane Protein Recognition by Farnesylation of the Peroxisomal Import Receptor PEX19 Nature Communications. 03, 2017 | Pubmed ID: 28281558 Long-range Allosteric Signaling in Red Light-regulated Diguanylyl Cyclases Science Advances. Mar, 2017 | Pubmed ID: 28275738 Catalytic Competence, Structure and Stability of the Cancer-associated R139W Variant of the Human NAD(P)H:quinone Oxidoreductase 1 (NQO1) The FEBS Journal. 04, 2017 | Pubmed ID: 28236663 Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent Angewandte Chemie (International Ed. in English). 11, 2016 | Pubmed ID: 27763708 Importance of Cycle Timing for the Function of the Molecular Chaperone Hsp90 Nature Structural & Molecular Biology. Nov, 2016 | Pubmed ID: 27723736 Crystal and Solution Structural Studies of Mouse Phospholipid Hydroperoxide Glutathione Peroxidase 4 Acta Crystallographica. Section F, Structural Biology Communications. 10, 2016 | Pubmed ID: 27710939 PRMT1-mediated Methylation of MICU1 Determines the UCP2/3 Dependency of Mitochondrial Ca(2+) Uptake in Immortalized Cells Nature Communications. Sep, 2016 | Pubmed ID: 27642082 Prediction of Protein Structure Using Surface Accessibility Data Angewandte Chemie (International Ed. in English). 09, 2016 | Pubmed ID: 27560616 Lysosomal Acid Lipase Regulates VLDL Synthesis and Insulin Sensitivity in Mice Diabetologia. Aug, 2016 | Pubmed ID: 27153842 Axin Cancer Mutants Form Nanoaggregates to Rewire the Wnt Signaling Network Nature Structural & Molecular Biology. Apr, 2016 | Pubmed ID: 26974125 Monomethylated and Unmethylated FUS Exhibit Increased Binding to Transportin and Distinguish FTLD-FUS from ALS-FUS Acta Neuropathologica. Apr, 2016 | Pubmed ID: 26895297 Structural Basis of Nucleic-acid Recognition and Double-strand Unwinding by the Essential Neuronal Protein Pur-alpha ELife. Jan, 2016 | Pubmed ID: 26744780 The Activity of Protein Phosphatase 5 Towards Native Clients is Modulated by the Middle- and C-terminal Domains of Hsp90 Scientific Reports. Nov, 2015 | Pubmed ID: 26593036 Optimization of Lipid Production with a Genome-scale Model of Yarrowia Lipolytica BMC Systems Biology. Oct, 2015 | Pubmed ID: 26503450 The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin The Journal of Biological Chemistry. Nov, 2015 | Pubmed ID: 26459561 Type-II NADH:quinone Oxidoreductase from Staphylococcus Aureus Has Two Distinct Binding Sites and is Rate Limited by Quinone Reduction Molecular Microbiology. Oct, 2015 | Pubmed ID: 26172206 Hsp90 Regulates the Dynamics of Its Cochaperone Sti1 and the Transfer of Hsp70 Between Modules Nature Communications. Apr, 2015 | Pubmed ID: 25851214 Introduction of Germline Residues Improves the Stability of Anti-HIV MAb 2G12-IgM Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 25748881 AAA+ Chaperones and Acyldepsipeptides Activate the ClpP Protease Via Conformational Control Nature Communications. Feb, 2015 | Pubmed ID: 25695750 A Compact Native 24-residue Supersecondary Structure Derived from the Villin Headpiece Subdomain Biophysical Journal. Feb, 2015 | Pubmed ID: 25650934 Hop/Sti1 Phosphorylation Inhibits Its Co-chaperone Function EMBO Reports. Feb, 2015 | Pubmed ID: 25504578 Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy Hansjörg Habisch*1, Fangrong Zhang*1,2, Qishun Zhou1, Tobias Madl1 1Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 2Ministry of Education, School of Basic Medical Sciences, Key Laboratory of Gastrointestinal Cancer (Fujian Medical University) JoVE 63245 Cancer Research
Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy Hansjörg Habisch*1, Fangrong Zhang*1,2, Qishun Zhou1, Tobias Madl1 1Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 2Ministry of Education, School of Basic Medical Sciences, Key Laboratory of Gastrointestinal Cancer (Fujian Medical University) JoVE 63245 Cancer Research