Name: y chromosome structure and male traits
Uploaded: 2021-04-07T12:11:58.000Z
Duration: 2 min 19 s
Channel: JoVE

K12 Standards

Louisiana Student Standards for Science

High School

Life Sciences

heredity-inheritance-and-variation-of-traits

Heredity: Inheritance And Variation Of Traits

HS-LS3-2

The Y Chromosome Determines Maleness

هناك نوعان من الكروموسومات الجنسية في البشر: X و Y.
يحدد كروموسوم Y الجنس الذكري وهو أصغر كروموسوم في الجينوم البشري.
هناك ثلاث مناطق في كروموسوم Y: الجزء الوراثي الكاذب ، والذي ينقسم أيضا إلى منطقتين - PAR1 و PAR2 ، والمنطقة غير المتجانسة ، والمنطقة اللونية.
يقع الجين S-R-Y في المنطقة اللونية من كروموسوم Y. يلعب دورا حيويا في نمو الأجنة الذكور.
عندما تندمج البويضة التي تحمل كروموسوم X مع منوي يحمل كروموسوم Y ، فإنها تشكل زيجوت.
ثم ينقسم البيض الملقح باستمرار لتشكيل جنين. في هذه المرحلة ، تتطور الأجنة من الذكور والإناث على طول نفس المسار وهي متطابقة من الناحية الفسيولوجية.
خلال المراحل المبكرة من التطور ، يحتوي الجنين على عضوين سلائف: قناة ولففيان وقناة مولريان.
يمكن أن تتمايز قناة Wolffian إلى هياكل تناسلية ذكرية ويمكن أن تتمايز قناة Mullerian إلى هياكل تناسلية أنثوية.
في الأسابيع التي تلي الإخصاب ، يتم نسخ جين S-R-Y الموجود على كروموسوم Y ثم ترجمته إلى بروتين S-R-Y. يبدأ بروتين S-R-Y في نمو الخصيتين في الجنين.
 يعمل بروتين S-R-Y كعامل نسخ ويرتبط بمواقع محددة على الحمض النووي ، وبالتالي ينشط مسار تكوين الخصيتين.
بعد ذلك ، تبدأ الغدد التناسلية في إفراز العديد من الهرمونات ، بما في ذلك الهرمون المضاد للمولر والتستوستيرون.
الهرمون المضاد للمولر يمنع تطور قناة مولريان.
التستوستيرون, من ناحية أخرى, يبدأ تطوير قناة وولفيان إلى الأسهر, قنوات القذف, والحويصلات المنوية.
إذا تعطل هذا المسار وفشلت الغدد التناسلية في إفراز هرمون التستوستيرون والهرمون المضاد للمولر ، فإن قناة مولر تتطور إلى أعضاء تناسلية أنثوية حتى لو كان الجنين XY وراثيا.

<ol>
	<li>ويلارد ، هنتنغتون ف. "حكايات كروموسوم Y". طبيعة سجية 423 ، رقم 6942 (2003): 811-813.</li>
	<li>جينالسكي ، كرزيستوف ، ليزيك ريشلوسكي ، ديفيد بيكر ، ف. جريشين. "التنبؤ ببنية البروتين للمنطقة الخاصة بالذكور من كروموسوم Y البشري". وقائع الأكاديمية الوطنية للعلوم 101 ، العدد 8 (2004): 2305-2310.</li>
	<li>نوردام ، ميشيل ج. ، وسيورد ريبينج "كروموسوم Y البشري: كروموسوم ذكوري". الرأي الحالي في علم الوراثة والتنمية 16 ، العدد 3 (2006): 225-232.</li>
</ol>

كروموسوم y يحدد الذكورة

<div style="direction: rtl;">
الكروموسوم Y هو كروموسوم جنسي موجود في العديد من الفقاريات والثدييات، بما في ذلك البشر. بالإضافة إلى 22 زوجًا من الجينات الجسدية، يمتلك الذكور كروموسوم X واحد وكروموسوم Y واحد. في هذه الكائنات، وجود أو عدم وجود كروموسوم Y يحدد تطور الصفات الذكورية.

التطور

منذ حوالي 300 مليون سنة، تباعدت الكروموسومات الجنسية عن اثنين من الكروموسومات الجسدية المتطابقة. مع مرور الوقت، فقد كروموسوم Y معظم جيناته، وتقلص حجمه. اليوم، جزء صغير فقط من كروموسوم Y يشترك في تشابه التسلسل مع كروموسوم X. أظهرت دراسة علمية كبيرة أجريت على كروموسومات Y في ثمانية ثدييات، بما في ذلك القرود والفئران والجرذان والثيران والأبوسوم والشمبانزي والبشر، وجود 18 منطقة متشابهة للغاية على كروموسومات Y. حقيقة أن هذه المناطق تم الاحتفاظ بها في جميع هذه الثدييات، على الرغم من فقدان جزء كبير من الكروموسومات Y أثناء التطور، توضح أن الجينات الموجودة على الكروموسومات Y حيوية لبقاء هذه الثدييات.

بناء

يحتوي كروموسوم Y في الثدييات على ثلاث مناطق رئيسية. تتشارك المناطق الجسمية الكاذبة الموجودة على الكروموسوم Y في التماثل مع الكروموسوم X ويمكن أن تخضع لإعادة التركيب الانتصافي. وهكذا، فإن الجينات الموجودة في المناطق الجسدية الكاذبة يتم توريثها بطريقة وراثية جسدية وليست مرتبطة بالجنس. المنطقة الثانية هي منطقة كروماتين حقيقي تم تحديدها كمنطقة كروموسوم Y خاصة بالذكور أو MSY. يبلغ طوله 23 ميغابايت ويحتوي على عدد قليل من جينات ترميز البروتين، مثل جين SRY، وهو منظم رئيسي للذكورة وجين ZFY المطلوب لتكوين الحيوانات المنوية. المنطقة الثالثة هي منطقة الكروماتين المتغاير التي تحتوي على عدة تسلسلات متكررة.

الطفرات وآثارها

تؤثر عمليات الحذف في منطقة MSY في كروموسوم Y على نمو الحيوانات المنوية وتسبب العقم عند الذكور. على سبيل المثال، تؤدي عمليات الحذف في جين AZF الموجود على الذراع الطويلة للكروموسوم Y إلى حالة تسمى فقد النطاف، حيث لا يتم العثور على الحيوانات المنوية في قذف الذكور. بالإضافة إلى ذلك، ترتبط عمليات الحذف في مناطق معينة من MSY بأورام الخلايا الجرثومية الخصية (TGCTs).
</div>

كروموسوم Y يحدد الذكورة

الكروموسوم Y هو كروموسوم جنسي موجود في العديد من الفقاريات والثدييات ، بما في ذلك البشر. بالإضافة إلى 22 زوجا من الجسيمات الجسدية ، فإن الإنسان ...

Education

JoVE Core

Molecular Biology

البيولوجيا الجزيئية

Unit 2

الوحدة الثانية

Mendelian Genetics

علم الوراثة المندلي

KEY TERMS AND CONCEPTS

المصطلحات والمفاهيم الأساسية

y chromosome structure and male traits

The Y chromosome is a sex chromosome that helps guide male development in humans and other vertebrates and mammals. Human males usually have one X chromosome and one Y chromosome, along with 22 pairs of autosomes. In these organisms, the presence or absence of the Y chromosome influences whether male traits develop.

The Y chromosome evolved from an autosome about 300 million years ago, when two sex chromosomes began to diverge. Since then, it has lost most of its genes and become much smaller. Only a small region still shares sequence similarity with the X chromosome. A large study of Y chromosomes in eight mammals, including monkeys, mice, rats, bulls, opossums, chimpanzees, and humans, found 18 highly similar regions. Their long-term retention suggests that Y-linked genes remain important for mammalian survival.

The mammalian Y chromosome has three main regions. The pseudoautosomal regions match parts of the X chromosome and can undergo meiotic recombination, which means they can be inherited more like autosomes than sex-linked genes. The second region is the male-specific Y chromosome region, or MSY. It is a euchromatin region about 23 Mb long and contains few protein-coding genes, including SRY, a master regulator of maleness, and ZFY, which is required for spermatogenesis. The third region is heterochromatin, which contains many repetitive sequences.

Changes in the MSY region can have major effects on reproduction. Deletions in this region can disrupt sperm development and lead to male sterility. For example, deletions in the AZF gene on the long arm of the Y chromosome can cause azoospermia, a condition in which spermatozoa are not found in the male ejaculate. Deletions in specific MSY regions are also linked to testicular germ cell tumors, or TGCTs.

Y Chromosome Structure and Male Traits

punnett squares

Predicting Traits with Punnett Squares

Punnett squares help students predict how traits may be passed from parents to offspring. They are a simple grid used in genetics to organize possible allele combinations. An allele is a version of a gene. The square compares the alleles each parent can give. By filling in the boxes, students can see possible genotypes, which are the genetic makeup of offspring. The results can also help connect those genotypes to traits that may appear in the next generation.

monohybrid crosses

Tracking One Trait in Monohybrid Crosses

Monohybrid crosses track how one trait is passed from parents to offspring. They are used to study inheritance when only a single characteristic is followed at a time. A monohybrid cross can compare the possible outcomes for a monogenic trait, which is a trait controlled by one gene. This approach helps show how one gene can shape different inherited forms of the same characteristic. The method also connects with Mendel's work on genetics. It is a useful way to predict patterns of inheritance...

dihybrid crosses

Predicting Two-Trait Genetic Crosses

Dihybrid crosses are used to predict how two traits can be passed from parents to offspring. A dihybrid cross tracks two genes at the same time, so it helps students see how different alleles can combine in a genetic pattern. This topic is closely tied to Mendelian genetics and independent assortment. Independent assortment means that allele pairs for different traits can separate into gametes independently of one another. When students work through a dihybrid cross, they can compare the...

trihybrid crosses

Forked Line Method for Trihybrid Crosses

Forked line method for trihybrid crosses helps predict the outcome of three-trait Mendelian crosses. A trihybrid cross studies three pairs of contrasting characteristics. It combines three separate monohybrid crosses. Common examples include plant height, seed shape, and seed color. In a typical trihybrid cross, the F1 plants are heterozygous for all three traits. They can produce eight different gametes. After self-fertilization, these gametes can lead to 64 genotype combinations in the F2...

law of independent assortment

Independent Chromosome Assortment in Meiosis

Independent chromosome assortment in meiosis explains how different gene pairs can be inherited independently. This idea is one of Mendel’s laws of inheritance and is often called the law of independent assortment. The pattern depends on how homologous chromosomes line up during meiosis I. Each chromosome pair orients independently of the others, so the maternal and paternal chromosomes can separate into different gametes in many combinations. This random separation helps create genetic...

chi-square analysis

Chi-Square Test in Genetics

The chi-square test in genetics helps compare expected and observed results. It is a statistical hypothesis test used to see whether a difference between an expected value and an observed value is significant. In genetics, it helps decide whether to accept or reject a hypothesis based on how far the observed data moves from the expected data. The test was developed by Pearson in 1990. The first step is to set up a null hypothesis. This hypothesis says there is no real difference between the...

pedigree analysis

Tracing Traits with Pedigree Charts

Pedigree analysis uses family trees, called pedigrees, to trace how traits and diseases pass from one generation to the next. A pedigree chart helps scientists and students see inheritance patterns clearly across relatives. The chart uses standard symbols to show family members and their relationships. It can reveal whether a trait is likely passed through dominant or recessive inheritance, and it can also help identify patterns linked to sex chromosomes. By studying a pedigree, it is...

multiple allele traits

Multiple Alleles in Trait Inheritance

Multiple alleles can shape how a trait is inherited in a population. A gene may have more than two allele forms, even though each person still carries only two alleles for that gene. These allele combinations can produce traits with more than two possible outcomes. The ABO blood group system is a common example of a multiple allele trait. It shows how different alleles can interact to determine an organism’s phenotype, or observable trait. Multiple allele traits help explain why inheritance...

incomplete dominance

Incomplete Dominance in Traits and Disease

Incomplete dominance is a pattern of inheritance where two alleles both affect a trait in a heterozygous organism. In this case, one allele is not fully dominant over the other. The result is a phenotype that looks like a blend or intermediate form. Gregor Mendel’s pea plant experiments helped explain the usual dominant and recessive pattern. He showed that each gene in a diploid cell has two alleles, one inherited from each parent. In his model, a dominant allele shows its effect with one or...

lethal alleles

When Genes Cause Embryonic Death

Lethal alleles can change inheritance patterns by causing death before birth. In mice, Lucien Cuénot studied the agouti gene, which helps control coat color through an agouti-signaling protein that affects melanin distribution in mammals. The wild-type allele produces a gray-brown coat, while the mutant allele produces a yellow coat. Cuénot also found that the yellow allele was linked to yellow mouse obesity syndrome. This syndrome is associated with early-onset obesity and tumors. When he...

polygenic traits

Traits Shaped by Many Genes

Polygenic traits are characteristics shaped by many genes acting together. This pattern is different from a single-gene trait, where one gene has a larger effect on the outcome. In polygenic inheritance, each gene adds a small contribution to the final trait. Height is a common example of a polygenic trait. Many genes influence human height, so the result can vary across a wide range. These small genetic effects combine to produce differences that are easy to see in a population. Polygenic...

background and environment affect phenotype

background-and-environment-affect-phenotype

How Genes and Environment Shape Traits

Genes and the environment work together to shape phenotype, or the visible traits of an organism. A phenotype can change because of genetic background, environmental conditions, or both. Factors such as temperature, oxygen availability, and mutagens can all influence how a trait appears. Horses show how one gene can affect coat color and how a modifier gene can change that result. The Extension gene controls pigment production in the coat. The wild-type genotype EE produces black pigment,...

x and y chromosomes

Sex Chromosomes in Human Inheritance

Sex chromosomes help determine biological sex in mammals, including humans. Humans have two sex chromosomes, X and Y. Each diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A female usually has two X chromosomes, while a male usually has one X chromosome and one Y chromosome. Egg and sperm cells carry only half the usual number of chromosomes. They contain 22 autosomes and one sex chromosome. Every egg has an X chromosome. Sperm cells can carry either an X or a Y...

the y chromosome determines maleness

The Y chromosome is a sex chromosome that helps guide male development in humans and other vertebrates and mammals. Human males usually have one X chromosome and one Y chromosome, along with 22 pairs of autosomes. In these organisms, the presence or absence of the Y chromosome influences whether male traits develop. The Y chromosome evolved from an autosome about 300 million years ago, when two sex chromosomes began to diverge. Since then, it has lost most of its genes and become much smaller.

the ratio of x chromosome to autosomes

Drosophila Sex Determination by X:A Balance

In Drosophila, sex is determined by the balance between X chromosomes and autosomes, not by the X and Y chromosomes alone. The Y chromosome is active in these flies, but it does not set sex. Instead, it carries genes needed for sperm production in adult males. A normal male Drosophila has one X chromosome and two sets of autosomes. A normal female has two X chromosomes and two sets of autosomes. When this X:A ratio changes, flies can develop different sexual phenotypes, including metamales,...

x-linked traits

X-Linked Inheritance in Families

X-linked inheritance in families explains how traits linked to the X chromosome pass from parents to children. These traits are often tracked through family trees because the pattern can differ between males and females. A male has one X chromosome and one Y chromosome. A female has two X chromosomes. Because of this difference, a trait on the X chromosome can show up in a different way depending on the sex of the child. Family examples often include traits such as color blindness. Studying...

sex linked disorders

Sex-Linked Disorders and Inheritance Patterns

Sex-linked disorders are genetic conditions that follow inheritance patterns tied to the sex chromosomes. These disorders help explain how certain traits can appear more often in one sex than the other. The transcript focuses on examples of sex-linked disorders, including Y-linked infertility, Fragile X syndrome, and Duchenne muscular dystrophy. Y-linked infertility is passed through the Y chromosome, while Fragile X syndrome and Duchenne muscular dystrophy are associated with sex-linked...

dosage compensation

X-Chromosome Balance in Animals

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x-inactivation

X-Inactivation and Barr Bodies

X-inactivation is a process that reduces gene activity on one X chromosome. It helps balance gene expression in cells that have more than one X chromosome. A key result of this process is the formation of a Barr body, which is the inactive X chromosome seen in the nucleus. This topic also includes Xist, a gene linked to X-inactivation. Xist produces RNA that coats the X chromosome and helps turn it off. Together, Xist and the Barr body show how cells control X-linked genes during development...

blood types

Blood Types and Transfusion Matching

Human blood types help determine safe blood transfusion matching. Blood is classified by antigens on the surface of red blood cells and antibodies in the plasma. Correct blood typing matters because an unsafe match can affect transfusion success. The International Society of Blood Transfusion has identified 38 human blood types, and ABO, Rh, and MNS are among the most common. The ABO blood group depends on antigens made by genes on chromosome 9. Red blood cells carry a base glycoprotein called...

blood transfusion and agglutination

Matching Blood Types for Safe Transfusion

Blood transfusion is a medical treatment used to restore blood volume after major blood loss from an accident or a medical procedure. It works by taking blood from a suitable donor and giving it to a recipient. Safe transfusion depends on matching blood types and checking for immune compatibility. The history of blood transfusion began in the 17th century, when early experiments were done in animals. In 1818, James Blundell, a British doctor, performed the first successful human blood...

key terms and concepts

Explore how the Y chromosome evolved, how its three regions differ, and how MSY deletions can affect sperm development and male fertility.

Y Chromosome Structure and Male Traits | JoVE K12

molecular biology

JoVE Core Molecular Biology showcases the molecular processes of the cell through clear and concise animated video lessons. Additionally, in scientist-in-action videos, these concepts' application is demonstrated through real experiments in modern laboratories.

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Ohio’s Learning Standards and Model Curriculum

9-12

Biology

Heredity

Genetic mechanisms and inheritance

Tennessee Academic Standards

links-among-engineering-technology-science-and-society

Links Among Engineering, Technology, Science, and Society

BIO1.ETS2.2

Alabama Course of Study Science

Heredity: Inheritance and Variation of Traits

9-12.B.3.11.a

Next Generation Science Standards

Life Science

HS-LS3-1

Texas Essential Knowledge and Skills

BIO.8

BIO.8.B

new-york-state-science-learning-standards

New York State Science Learning Standards

Inheritance and Variation of Traits

HS-LS3-1.

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Euchromatin

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Heterochromatin

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Chromatin Position Affects Gene Expression

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Punnett Squares

Monohybrid Crosses

Dihybrid Crosses

Trihybrid Crosses

Trihybrid Crosses
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Law of Independent Assortment

Chi-square Analysis

The chi-square test is a statistical hypothesis test. It is used to check whether there is a significant difference between an expected value and an ...

Pedigree Analysis

Multiple Allele Traits

Incomplete Dominance

Gregor Mendel&#39;s work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid ...

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cu&#233;not discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is ...

Polygenic Traits

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as ...

Formulate, refine, and evaluate questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring. Emphasis should be on traits including completely dominant, codominant, incompletely dominant, and sex-linked traits (e.g., pedigrees, karyotypes, genetic disorders, Punnett squares). Examples do not need to include dihybrid crosses.

X and Y Chromosomes

Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 ...

The Y chromosome is a sex chromosome&#160;found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human ...

The Ratio of X Chromosome to Autosomes

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X-linked Traits

Sex Linked Disorders

Dosage Compensation

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X-inactivation

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Meiosis I

Meiosis II

Make and defend a claim based on evidence that inheritable genetic variations may result from: (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors. Emphasis is on using data to support arguments for the way variation occurs. Claims should not include the phases of meiosis or the biochemical mechanisms of specific steps in the process.

Y Chromosome Structure and Male Traits

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