HSQC NMR Maps Carbon-Proton Connections

HSQC NMR maps the direct links between hydrogen atoms and the carbons they are attached to. It is a 2D NMR method, so it shows the data on two axes instead of one. The experiment is similar to heteronuclear correlation spectroscopy, or HETCOR, but HSQC is more sensitive.

In an HSQC spectrum, the ...

Heteronuclear single-quantum correlation spectroscopy or HSQC is a sensitive 2D NMR technique that correlates heteronuclear spins coupled across a single bond.

A ¹H–¹³C HSQC spectrum correlates the proton chemical shift plotted on the horizontal F₂ axis to the carbon-13 chemical shift along the ve...