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Chemistry

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Organic Chemistry

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Carboxylic Acid Derivatives

Water Attack on Acid Halides

Description

Acid halides react with water in a nucleophilic acyl substitution reaction to form carboxylic acids. This reaction happens readily and does not need an acid catalyst or a base catalyst.

The mechanism begins when water acts as a nucleophile and attacks the carbonyl carbon. This forms a tetrahedral...

Transcript

Hydrolysis of acid halides is a nucleophilic acyl substitution reaction, where an acid halide reacts with water to form a carboxylic acid.

Since acid halides are very reactive, the hydrolysis does not require an acid or a base catalyst.

The mechanism proceeds in three steps. The first step is the nucleophilic attack by water at the...

Tags

Hydrolysis ReactionNucleophilic Acyl SubstitutionTetrahedral IntermediateProton Transfer StepHalide Ion DeparturePyridine BaseHCl ByproductOrganic Reaction Mechanism