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Carboxylic Acid Derivatives
Water Attack on Acid Halides
Description
Acid halides react with water in a nucleophilic acyl substitution reaction to form carboxylic acids. This reaction happens readily and does not need an acid catalyst or a base catalyst.
The mechanism begins when water acts as a nucleophile and attacks the carbonyl carbon. This forms a tetrahedral...
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Transcript
Hydrolysis of acid halides is a nucleophilic acyl substitution reaction, where an acid halide reacts with water to form a carboxylic acid.
Since acid halides are very reactive, the hydrolysis does not require an acid or a base catalyst.
The mechanism proceeds in three steps. The first step is the nucleophilic attack by water at the...
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