Grignard Reagents Make Tertiary Alcohols

Grignard reagents, also called organomagnesium halides, can turn acid halides into tertiary alcohols. This reaction uses two equivalents of the Grignard reagent and goes through a ketone intermediate.

A Grignard reagent acts as a nucleophile, which means it donates electron-rich carbon in the for...

In addition to lithium aluminum hydride, organomagnesium halides, known as Grignard reagents, convert acid halides to alcohols.

Unlike the first approach, where the final product is a primary alcohol, reduction with the Grignard reagent yields a tertiary alcohol.

The reaction requires two equivalents of the Grignard reagent and pro...