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Nuclear transmutation is the conversion of one element into another through radioactive decay, nuclear fusion, or nuclear fission. Ernest Rutherford first demonstrated this in 1919 by bombarding nitrogen-14 with alpha particles, producing a proton and oxygen-17. Transmutation can occur naturally through radioactive decay or artificially when nuclei are bombarded with particles like neutrons or alpha particles.

Neutrons are electrically neutral and encounter no electrostatic repulsion from positively charged target nuclei, so fission speeds are sufficient for transmutation. Alpha particles, being positively charged, must overcome electrostatic repulsion and thus require greater kinetic energy. This repulsion is even stronger with larger nuclei like plutonium-239 than with smaller nuclei like nitrogen-14.

Transuranium elements are synthetic elements with atomic numbers greater than 92 (uranium), except neptunium and plutonium, which also occur naturally in uranium decay chains. These elements are created through transmutation reactions in specialized nuclear reactors. For example, neptunium-239 is generated by bombarding uranium-238 with fission neutrons, which then decays into plutonium-239.

Particle accelerators use magnetic and electric fields to increase the speeds of nuclear particles to levels necessary for transmutation. Linear accelerators use alternating electrical potential to accelerate particles through tubes of increasing length, reaching speeds exceeding 90% of light speed. Cyclotrons accelerate particles in a spiral path using alternating voltage, allowing bombardment of nuclei with high-energy particles.

Condensed notation for transmutation lists, in order, the target nucleus, the bombarding particle, the ejected particle, and the product nucleus. This format provides a concise way to represent the entire reaction. For example, Rutherford's experiment with nitrogen-14 bombarded by alpha particles producing a proton and oxygen-17 follows this systematic notation.

Uranium-238 is bombarded with neutrons released during uranium-235 decay in nuclear reactors. This creates unstable uranium-239, which undergoes beta decay to form neptunium-239. Neptunium-239 subsequently undergoes radioactive decay and radiometric dating processes to form plutonium-239, which is now mostly formed as a byproduct during uranium decay.

Nuclear medicine has developed from the ability to convert atoms of one type into other types through transmutation. Radioactive isotopes of several dozen elements are now used for medical applications, with radiation from their decay used to image or treat various organs and body portions. This advancement demonstrates the practical benefits of transmutation technology beyond fundamental nuclear research.