Aortotomy Repair
Aortotomy Repair - Related Videos
02:25
Overview of DNA Repair
0 Views •
2020
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage. Chemically...
01:54
Base Excision Repair
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2020
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template. The first step of...
01:02
Long-patch Base Excision Repair
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2020
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are: Lesion type: Depending on the type of base damage, a specific DNA glycosylase - mono or bifunctional, is recruited to the damaged site. While the sequential action of a monofunctional glycosylase favors long patch repair...
07:32
Murine Flexor Tendon Injury and Repair Surgery
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Cited by 45 •
2016
Flexor tendons in the hand are commonly injured, leading to impaired hand function. However, the scar-tissue healing response is not well characterized. A murine model of flexor tendon healing is demonstrated here. This model can enhance overall understanding of the healing process and assess therapeutic approaches to improve healing.
01:48
Mismatch Repair
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2020
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.The Mutator Protein Family Plays a Key Role in DNA Mismatch RepairThe human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
FAQs
The condition of the aortic wall guides reconstruction. When the incision can be closed without removing or replacing damaged tissue, vascular sutures may approximate the wall directly. Tissue loss or structural damage can prevent that approach, making a patch or graft necessary. This choice helps restore continuity while addressing limitations created by the original procedure.
The repair must maintain the internal passage of the aorta as the wall is brought together. Excessive distortion or narrowing could interfere with blood flow, whereas careful approximation supports a continuous lumen. Preserving this geometry connects the mechanical act of suturing with the biological purpose of the repair: maintaining vascular function after the incision has been closed.
A secure closure addresses several risks associated with an aortic incision. It helps control blood loss during repair and reduces the possibility of leakage afterward. Maintaining wall integrity also limits the risk of later weakening at the repaired site. These goals explain why suture placement, tissue approximation, and reconstruction choice are central to the outcome.
The repair begins with control of bleeding at the aortic incision. The surgeon then evaluates how the aortic wall can be reconstructed, approximates the tissue with vascular sutures when direct closure is suitable, and uses a patch or graft if tissue loss or structural damage prevents that approach. Each step supports continuity and vascular integrity.
A patch or graft may be selected when the aortic wall has tissue loss or structural damage that makes simple edge-to-edge closure unsuitable. These materials provide an alternative means of reconstructing the affected segment. Their use is therefore tied to the condition of the tissue, rather than being required for every aortic incision.
This repair provides a model for examining how vascular tissue responds after injury and reconstruction. In biology, it can support study of wound healing, preservation of vascular integrity, and postoperative complications. The procedure therefore links surgical repair with broader questions about how a vessel maintains structure and function after its wall has been incised.