Cardiac Cycle

The cardiac cycle is the sequence of mechanical events that occurs during one heartbeat, allowing the heart to fill with blood and pump it through the pulmonary and systemic circulations. It alternates between diastole, when the atria and ventricles relax and fill, and systole, when the ventricles contract; changes in chamber pressure open and close the atrioventricular and semilunar valves, directing one-way blood flow. Understanding the cardiac cycle helps explain heart sounds, pulse patterns, cardiac output, and blood pressure, while providing a foundation for studying cardiovascular physiology and conditions that disrupt rhythm, valve function, or pumping efficiency.

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JoVE Core - Anatomy and Physiology

Cardiac Cycle

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2025

The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles. During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...

The Cardiac Cycle

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2025

The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole). The Process Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and empty blood into the...

Physiology of the Heart: The Cardiac Cycle

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2025

The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves. Diastole: The Relaxation Phase During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...

Correlation between ECG and Cardiac Cycle

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2025

The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle. A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...

Cardiac Magnetic Resonance Imaging

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2023

Source: Frederick W. Damen and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana In this video, high field, small-bore magnetic resonance imaging (MRI) with physiological monitoring is demonstrated to acquire gated cine loops of the murine cardiovascular system. This procedure provides a basis for assessing left-ventricular function, visualizing vascular networks, and quantifying motion of organs due to respiration. Comparable small animal...

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