Intracerebral Blood Flow
Intracerebral Blood Flow - Related Videos
10:44
Modeling Intracerebral Hemorrhage in Mice: Injection of Autologous Blood or Bacterial Collagenase
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Cited by 60 •
2012
Clinically relevant animal models of intracerebral hemorrhage (ICH) are needed to extend our knowledge of hemorrhagic stroke and to examine novel therapeutic strategies. In this study, we describe and evaluate two ICH models that implement unilateral injections of either autologous whole blood or bacterial collagenase into the basal ganglia (corpus striatum) of mice.
07:02
Autologous Blood Injection to Model Spontaneous Intracerebral Hemorrhage in Mice
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Cited by 28 •
2011
The autologous blood injection model of intracerebral hemorrhage in mice described in this protocol uses the double injection technique to minimize risk of blood reflux up the needle track, no anticoagulants in the pumping system, and eliminates all dead space and expandable tubing in the system.
03:38
Developing a Cerebral Blood Flow Atlas for Blood Flow Mapping
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2025
Source: Tan, Z., et al., Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling. J. Vis. Exp. (2024).This video demonstrates the method to construct a cerebral blood flow atlas by integrating magnetic resonance imaging or MRI-arterial spin labeling data with segmented brain regions, visualizing blood flow patterns, and quantifying flow levels across functional areas.
01:29
Blood Flow
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2025
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow. Slow...
09:41
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
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Cited by 35 •
2014
Preclinical models of intracerebral hemorrhage are utilized to mimic certain aspects of clinical disease. Thus, mechanisms of injury and potential therapeutic strategies may be explored. In this protocol, two models of intracerebral hemorrhage are described, intrastriatal (basal ganglia) injections of autologous blood or collagenase.
FAQs
Cerebral autoregulation allows brain arterioles to adjust their diameter as arterial pressure changes. By constricting or dilating, these vessels help preserve adequate perfusion instead of simply allowing blood flow to rise or fall in direct proportion to pressure. This protective adjustment supports the continued delivery of oxygen and glucose to neurons and glial cells.
Carbon dioxide levels and local chemical signals provide information about the brain’s immediate metabolic environment. Their effects on arteriolar diameter help regulate perfusion according to changing tissue needs. This mechanism complements pressure-based autoregulation, allowing blood supply to respond not only to systemic conditions but also to local demands within the brain.
Neural activity can change local requirements for oxygen and glucose, so it becomes one of the signals that influences arteriolar diameter. This links vascular regulation with functional demand: regions with changing activity can receive appropriately adjusted perfusion while waste removal continues. Studying this relationship helps explain how the brain supports ongoing cellular function.
Brain injury and disease can alter the conditions under which adequate perfusion is maintained, making blood-flow assessment especially informative. Examining intracerebral blood flow helps researchers investigate how the vascular supply responds in disorders such as stroke, traumatic brain injury, tumors, and neurodegeneration. It also provides context for understanding changes in brain function during illness.
Measurements of cerebral perfusion indicate how effectively blood is reaching brain tissue under particular physiological or experimental conditions. Researchers can use these data to examine whether oxygen and glucose delivery may meet changing cellular demands and to evaluate vascular responses associated with disease, injury, anesthesia, or other interventions affecting brain function.
Assessment is useful whenever investigators need to connect vascular supply with brain function or pathology. Applications include research on stroke, traumatic brain injury, tumors, neurodegeneration, and the effects of anesthesia or other interventions. Comparing perfusion in these contexts can clarify how altered blood delivery relates to tissue demands and functional outcomes.