Particle Manipulation
Particle Manipulation - Related Videos
13:27
Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
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Cited by 50 •
2014
Pneumonia is one of the top ten leading causes of death in the U.S. Osteopathic manipulative techniques (OMT) may be utilized as an adjunctive therapy in the treatment of pneumonia to enhance biomechanical and immune function; and ultimately, to reduce hospital stay, duration of antibiotics, incidence of respiratory failure, and mortality. In this video-article, we will review randomized controlled studies on the use of OMT in pneumonia patients, as well as demonstrate specific hands-on...
03:37
Subatomic Particles
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2020
Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...
02:41
Concentration and Purification of Viral Particles
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2026
Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016).This video demonstrates the step-by-step process for concentrating and purifying lentiviral particles from a mixed suspension containing host cell debris. The procedure utilizes centrifugation, filtration, and PEG-salt precipitation to isolate viral particles while removing soluble impurities. The final product is resuspended in a...
07:20
Trapping of Micro Particles in Nanoplasmonic Optical Lattice
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2017
We describe a procedure to optically trap micro-particles in nanoplasmonic optical lattice.
02:10
The Nucleosome Core Particle
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2020
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins. The paradox Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
FAQs
The choice of physical force is matched to both the biological particle and the experimental objective. Optical, magnetic, acoustic, electric, and fluidic systems can produce different ways of changing a particle’s trajectory, position, concentration, or isolation state. This matching determines whether the experiment emphasizes precise handling, population separation, sample preparation, or observation of cell behavior.
Defined conditions help researchers control how biological particles move, position, concentrate, separate, or remain trapped during an experiment. This control is important in small-volume systems, where the intended outcome depends on consistent handling rather than bulk-scale operations. Maintaining specified conditions also supports reproducible sample preparation, cell analysis, and investigations of cell behavior.
Unlike bulk-scale handling, particle manipulation targets cellular or subcellular objects within small-volume experiments. This scale allows researchers to alter trajectories, concentrate selected material, or isolate populations while limiting reliance on manual handling. The resulting control is especially relevant when the biological question concerns individual cells, organelles, or other microscopic particles rather than an undifferentiated sample.
A basic workflow begins by identifying the biological particles and the intended outcome, then selecting a system based on the available force types and particle properties. The system is applied under defined experimental conditions to move, position, concentrate, separate, or trap the targets. Researchers can then use the resulting arrangement or isolated population for downstream analysis, preparation, or behavioral study.
It supports cell sorting, sample preparation, single-cell analysis, diagnostics, and studies of cell behavior. The same general capability can therefore serve both operational and investigative purposes: researchers may prepare or isolate biological material, examine individual cells, or evaluate how cells behave under controlled manipulation. These uses make the approach relevant across biological experiments that require precise handling at small scales.
Lab-on-a-chip platforms benefit because manipulation can be integrated into small-volume experiments rather than relying on bulk-scale tools. In single-cell and subcellular studies, the approach provides a way to handle cells, organelles, and related particles with controlled positioning or separation. This integration supports compact experimental systems and can reduce manual handling while preserving access to biologically meaningful targets.