Perivascular Niche
Perivascular Niche - Related Videos
07:05
Use of Human Perivascular Stem Cells for Bone Regeneration
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Cited by 42 •
2012
Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo.
09:05
A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Cited by 4 •
2017
Here we present a novel clinical grade isolation and culture method for kidney Perivascular Stromal Cells (kPSCs) based on whole organ perfusion with digestive enzymes and NG2-cell enrichment. With this method, it is possible to acquire sufficient cell numbers for cellular therapy.
08:15
Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Cited by 7 •
2016
Human cardiac tissue harbours multipotent perivascular precursor cell populations that may be suitable for myocardial regeneration. The technique described here allows for the simultaneous isolation and purification of two multipotent stromal cell populations associated with native blood vessels, i.e. CD146+CD34- pericytes and CD34+CD146- adventitial cells, from the human myocardium.
02:02
Ecological Niches
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2026
All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.Multiple species cannot occupy the exact same niche within their habitat. If the niches of two or more species overlap to a large extent, the competitive exclusion principle dictates that one species will outcompete the other, forcing it to...
01:12
Ecological Niche
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2026
Microorganisms occupy diverse habitats and perform essential ecological functions that are defined by their ecological niches. A microbial niche encompasses the organism’s mode of survival, including resource acquisition, reproduction, and interactions with other species in its environment. This concept is vital for understanding microbial community dynamics, biogeography, and ecosystem functionality.The fundamental niche of a microorganism includes the full spectrum of environmental...
FAQs
Endothelial cells form the vascular interface, while pericytes and extracellular matrix provide supporting cellular and structural influences. Together, these components help regulate signals reaching nearby cells and shape whether stem cells remain maintained, become activated, migrate, or differentiate. Their coordinated activity connects vessel behavior with changes in surrounding tissue rather than treating blood vessels as passive conduits.
These conditions can shift the signals and cellular interactions that govern the local tissue environment. Injury and inflammation may change how nearby cells respond, while oxygen availability and vascular remodeling can modify the context in which stem cells receive regulatory cues. As a result, the same niche may support homeostasis in one state but promote repair or altered tissue behavior in another.
Signals produced locally or delivered through circulation help connect vascular activity with the decisions of nearby stem cells. Their combined influence can affect maintenance, activation, migration, and differentiation. This makes the perivascular niche a signaling environment in which stem cell behavior reflects both conditions within the tissue and information associated with the bloodstream.
The same regulatory relationships that help preserve tissue homeostasis and support repair can become associated with pathological changes. Altered vascular or supporting-cell interactions are relevant to research on cancer, fibrosis, and vascular disorders. Examining these interactions can therefore clarify how a tissue moves from controlled maintenance toward abnormal remodeling or impaired recovery.
A useful model should represent the interactions among vascular cells, supporting cells, extracellular matrix, and relevant signals. It should also allow investigators to consider changing conditions such as injury, inflammation, oxygen availability, or vascular remodeling. Reproducing these relationships helps researchers examine how the niche influences stem cell behavior and tissue responses rather than studying each component in isolation.
Studies of this niche can reveal how tissues preserve homeostasis, respond to damage, and regulate stem cell activity. They can also connect changes in blood vessel function with migration, differentiation, and broader tissue behavior. These outcomes provide a framework for investigating regeneration as well as disease processes involving cancer, fibrosis, or vascular dysfunction.
Niche research can inform which vascular, supporting-cell, extracellular-matrix, and signaling relationships should be represented when designing engineered tissues. It may also help shape strategies for cell-based therapies by accounting for the environment that influences implanted or recruited cells. Incorporating these interactions could improve the biological relevance of tissue models and therapeutic approaches.