Tissue Harvesting Device
Tissue Harvesting Device - Related Videos
12:29
Sterile Tissue Harvest
0 Views •
2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN In 1959 The 3 R's were introduced by W.M.S. Russell and R.L. Burch in their book The Principles of Humane Experimental Technique. The 3 R's are replacement, reduction, and refinement of the use of animals in research. The use of cell lines and tissue cultures that originated from research animals is a replacement technique, as it allows for many experiments to be conducted in vitro. Harvesting...
21:15
Diagnostic Necropsy and Tissue Harvest
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2016
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN Many animal experiments rely on final data collection time points that are gathered from the harvesting and testing of organs and tissues. The use of appropriate methods for the collection of organs and tissues can impact the quality of the samples and the analysis of the data that is gleaned for the testing of the tissues. The method of euthanasia of the animal can also impact the quality of...
06:06
Apparatus for Harvesting Tissue Microcolumns
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Cited by 7 •
2018
Here we describe a protocol for producing harvesting needles that can be used to collect full-thickness skin tissue without causing donor site scarring. The needles can be combined with a simple collection system to achieve high-volume harvesting.
11:08
Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
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2025
Here, we present a protocol to fabricate a unique two-layer microfluidic device to study the electromechanical regulation of epithelial tissue homeostasis. The device applies static physiological electric currents perpendicular to the tissue plane, impacting cell-cell adhesion, proliferation, and extrusion. Live-cell imaging and mechanical stress measurements reveal mechanisms of these processes.
08:29
Thermal Measurement Techniques in Analytical Microfluidic Devices
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Cited by 6 •
2015
Here, we present three protocols for thermal measurements in microfluidic devices.
FAQs
Each mechanism interacts with tissue differently, so the collection action can influence how much mechanical damage occurs and how well the specimen retains its original structure. Cutting separates tissue, grasping secures it, coring removes a tissue section, and suction collects material through aspiration. Choosing among these mechanisms helps align sample quality with later examination, culture, analysis, or storage.
Mechanical damage can alter the specimen before examination or processing, potentially weakening the connection between tissue architecture, cellular features, and biochemical function. A suitable device limits unnecessary disruption while collecting enough material for the intended assay or analysis. Preserving both structure and viability is therefore important when the sample will support histology, cell isolation, or culture.
Device selection affects several linked outcomes: sample quality, collection efficiency, contamination risk, and the reliability of downstream results. A device that collects tissue efficiently but causes excessive disruption may compromise structural or viability-dependent work, while an unsuitable collection approach can reduce the usefulness of the specimen. Selection should therefore reflect the planned biological analysis and handling needs.
A basic workflow starts by selecting a device whose collection mechanism matches the specimen and intended downstream purpose. Tissue is then removed using the device while limiting unnecessary damage and contamination. The collected material proceeds to examination, culture, analysis, or storage, depending on the study design. This workflow connects the physical collection step with the reliability of later biological measurements.
Harvested tissue can support histology, molecular assays, cell isolation, disease research, culture, analysis, and storage. These applications require different properties from the collected specimen, including preserved architecture, viable material, or suitable biochemical content. The device and collection approach consequently become part of experimental planning rather than isolated equipment choices, because they influence what information the tissue can provide.
Biological interpretation often depends on relating visible tissue organization to events at cellular and biochemical levels. A well-collected specimen can provide material for histology alongside molecular assays or cell isolation, allowing these perspectives to be examined together. In disease research, that relationship helps investigators study how changes in tissue structure correspond with cellular or biochemical function.