Trabecular Meshwork Exposure
Trabecular Meshwork Exposure - Related Videos
09:03
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Cited by 7 •
2015
Trabecular meshwork (TM) migration into Schlemm’s canal space can be induced by acute pressure elevation by ophthalmodynamometer, and observed by spectral domain optical coherence tomography. The goal of this method is to quantify the morphometric response of the living outflow tract to acute pressure elevation in living tissues in situ.
13:47
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Cited by 5 •
2018
Here, we describe a protocol for a reproducible laser capture microdissection (LCM) for isolating trabecular meshwork (TM) for downstream RNA analysis. The ability to analyze changes in gene expression in the TM will help in understanding the underlying molecular mechanisms of TM-related ocular diseases.
09:46
Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening
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Cited by 9 •
2018
This manuscript describes a murine calvarial osteolysis model by exposure to CoCrMo particles, which constitutes an ideal animal model for assessing the interactions between wear particles and various cells in aseptic loosening.
09:36
Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
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2018
We present a workflow for segmenting and quantifying trabecular bones for 2D and 3D images based on the bone's outer boundary using an ImageJ plugin. This approach is more efficient and accurate than the current manual hand-contouring approach, and provides layer-by-layer quantifications, which are not available in current commercial software.
09:08
Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens
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Cited by 11 •
2016
In the current climate of scarce resources, new technologies are emerging that allow researchers to conduct studies cheaper, faster and with more precision. Here we describe the development of a bead-based salivary antibody multiplex immunoassay to measure human exposure to multiple environmental pathogens simultaneously.
FAQs
Exposure focuses investigation on the iridocorneal angle and the drainage pathway leading toward Schlemm’s canal. By making this region visible or accessible, researchers can examine how the meshwork is positioned in relation to the canal and evaluate the tissue responsible for directing aqueous humor into that pathway. This supports detailed anatomical analysis of ocular fluid drainage.
Overlying ocular tissues can limit direct access to the trabecular meshwork. Opening or removing them creates a clearer route for observation, measurement, or treatment directed at the drainage region. The resulting access is important because studies can focus on the meshwork itself rather than relying only on indirect observations of aqueous humor movement or intraocular pressure.
The same exposed region can provide different kinds of biological information. Investigators may examine the meshwork anatomically, measure outflow facility, or analyze cellular and molecular features. These approaches address complementary questions: structural work describes the drainage tissue, functional measurements assess aqueous humor outflow, and cellular or molecular studies examine biological characteristics within the exposed region.
A general workflow begins by opening or removing selected overlying ocular tissues to reveal the iridocorneal angle and trabecular meshwork. After access is established, the exposed region can be examined, measured, or used for treatment-related studies. The specific endpoint depends on whether the investigation emphasizes anatomy, outflow facility, cellular and molecular analysis, or therapeutic evaluation.
Researchers use this approach when they need to examine or target the drainage pathway relevant to elevated intraocular pressure. It can support evaluation of glaucoma therapies designed to improve aqueous humor drainage, while also allowing anatomical and functional assessment of the treated region. This connects tissue-level observations with the broader goal of understanding or reducing impaired ocular outflow.
Trabecular meshwork exposure can yield anatomical observations, outflow facility measurements, and cellular or molecular information. It also provides access for assessing treatments intended to improve aqueous humor drainage. Together, these outcomes help investigators relate the condition of the drainage tissue to fluid movement and to the potential effectiveness of glaucoma interventions aimed at reducing elevated intraocular pressure.