Sclerotherapy

Sclerotherapy is a minimally invasive treatment that closes unwanted or abnormal blood vessels by injecting a sclerosant, making it important in the clinical management of venous disease and selected vascular lesions. The agent irritates the vessel’s endothelial lining, triggering inflammation, blood clot formation, and eventual fibrosis that seals the treated vessel and redirects blood flow to healthier veins. Clinicians commonly use liquid or foam formulations to treat varicose and spider veins, while ultrasound guidance can improve targeting of deeper vessels. Sclerotherapy can reduce visible veins and related symptoms, although treatment selection depends on vessel size, location, and patient factors.

Sclerotherapy - Related Videos

Research

JoVE Journal - Medicine

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices

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2025

Underwater endoscopic injection sclerotherapy might be a choice for patients with gastroesophageal varices (GEVs). The decreased peristalsis of the esophagus underwater can increase the success rate of intravascular injection and stabilize the vision.

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

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2025

This protocol presents the management for gastroesophageal varices (GEVs) with endoscopic injection sclerotherapy assisted by cyanoacrylate and clips (CISC), which can improve the effectiveness of sclerotherapy and reduce complications.

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