Ventricular Assist Devices

Ventricular assist devices (VADs) are mechanical pumps that support a weakened heart by moving blood from a ventricle to the pulmonary artery or systemic circulation. Most commonly used as left ventricular assist devices (LVADs), they draw blood from the left ventricle and propel it through the aorta using an implanted pump, often with continuous-flow technology; an external controller and power source regulate operation. In clinical care, VADs can stabilize patients with advanced heart failure while they await transplantation, support recovery after acute cardiac injury, or provide long-term destination therapy. Their use improves circulation but requires careful monitoring for bleeding, infection, thrombosis, and device malfunction.

Ventricular Assist Devices - Related Videos

Research

JoVE Journal - Medicine

Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart

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Cited by 4 •

2018

Here, we present a protocol using two centrifugal pumps as a total artificial heart replacement.

In Vitro Thrombosis Test for Ventricular Assist Devices

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2025

We present a benchtop protocol to induce thrombosis in ventricular assist devices (VAD) within a recirculating test platform. This method serves to identify thrombogenic hotspots in the blood flow path and can help improve thromboresistance ahead of preclinical testing in animal models.

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

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2026

This article presents a protocol to implant the left ventricular assist device (LVAD) into a piglet. This model represents a potent way to study the LVAD implantation in children and reveal the mechanism of ventricular reverse remodeling in LVAD treatment.

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

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2021

Percutaneous ventricular assist devices are increasingly being utilized in patients with acute myocardial infarction and cardiogenic shock. Herein, we discuss the mechanism of action and hemodynamic effects of such devices. We also review algorithms and best practices for the implantation, management and weaning of these complex devices.

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

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Cited by 1 •

2021

The following article describes the stepwise procedure for placement of a device (e.g., Tandemheart) in cardiogenic shock (CS) that is a percutaneous left ventricular assist device (pLVAD) and a left atrial to femoral artery bypass (LAFAB) system that bypasses and supports the left ventricle (LV) in CS.

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