Carbapenem-resistant Organisms
Carbapenem-resistant Organisms - Related Videos
08:12
Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
0 Views •
Cited by 7 •
2018
Robust functional catechol coatings were produced in one step by direct reaction of the material known as HKUST with synthetic catechols under anaerobic conditions. The formation of homogeneous coatings surrounding the entire crystal is ascribed to the biomimetic catalytic activity of Cu(II) dimers on the external surface of the crystals.
10:51
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
0 Views •
Cited by 41 •
2017
This publication describes the fabrication of an organ-on-chip device with integrated electrodes for direct quantification of transendothelial electrical resistance (TEER). For validation, the blood-brain barrier was mimicked inside this microfluidic device and its barrier function was monitored. The presented methods for electrode integration and direct TEER quantification are generally applicable.
02:18
Types of Genetic Transfer Between Organisms
0 Views •
2020
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
01:22
Resistivity
0 Views •
2023
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as: where σ is the electrical conductivity and is represented...
01:19
Resistance
0 Views •
2023
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
FAQs
Carbapenemases are enzymes that hydrolyze carbapenem antibiotics, directly disabling the drug before it can exert its antibacterial effect. However, reduced entry through outer-membrane porins and increased efflux can also lower bacterial exposure to the antibiotic. Recognizing which mechanism contributes helps explain resistance patterns and supports appropriate diagnostic interpretation.
A single organism may combine carbapenemase activity with reduced porin entry or increased efflux. These mechanisms can reinforce one another, producing a resistance phenotype that is not explained by one process alone. Such combinations complicate susceptibility testing because the observed result reflects multiple influences on antibiotic activity rather than a single resistance determinant.
Disease severity depends not only on bacterial resistance but also on host-pathogen interactions. Innate immune defenses and inflammation shape how the host responds, while immunocompromised states can alter disease severity and transmission. Studying these factors connects organism identification with the biological context that determines clinical and infection-control importance.
Identification supports several connected goals: rapid diagnostics, antimicrobial selection, surveillance, and infection-control planning. In practice, recognizing the resistant phenotype alerts researchers and clinical teams that carbapenem treatment may be compromised and that additional information is needed to guide antimicrobial decisions and monitor public-health threats.
Susceptibility results may reflect carbapenemase-mediated drug hydrolysis, reduced antibiotic entry through outer-membrane porins, increased efflux, or combinations of these mechanisms. Because different processes can produce or intensify the resistant phenotype, testing requires careful interpretation. This complexity matters when selecting antimicrobials and assessing whether treatment options may be limited.
CRO identification provides information for tracking resistant organisms and recognizing threats that may affect clinical care and public health. Surveillance can clarify where resistant phenotypes occur, while infection-control strategies use that information to address transmission risk. Immunology and infection research adds context by examining how host defenses and immunocompromised states influence outcomes.