Organ Injury
Organ Injury - Related Videos
04:24
Bipolar Radiofrequency-Based Hemorrhage Arrest in Solid Organ Injury: A Technique to Arrest Bleeding in Porcine Model With Liver Injury Using Electrosurgery
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2025
This video demonstrates a technique of bipolar radiofrequency energy-based transcollation for hemorrhage arrest in solid organ injury in a porcine model. This method is helpful for the surgical management of traumatic injury by achieving hemostasis by arresting bleeding at the injury site.
01:35
Organ-on-Chip Models
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2026
Introduction to Organ-on-Chip Models Organ-on-chip models are advanced microphysiological systems that recreate key structural and functional features of human organs in a controlled laboratory setting. These devices integrate living human cells within microfluidic channels, allowing researchers to simulate tissue–tissue interfaces, fluid flow, and mechanical forces that are essential for normal organ function. Unlike traditional cell cultures, which often lack these dynamic physiological cues,...
07:28
Controlled Cervical Laceration Injury in Mice
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Cited by 17 •
2013
A novel technique to create a reproducible in vivo model of cervical spinal cord laceration injury in the mouse is described. This technique is based on spine stabilization by fixation of the cervical facets and laceration of the spinal cord using an oscillating blade with an accuracy of ±0.01 mm.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
09:46
Training Persons with Spinal Cord Injury to Ambulate Using a Powered Exoskeleton
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Cited by 58 •
2016
Training a person with paralysis to ambulate using a powered exoskeleton may present challenges. The goals are to present the candidate selection criteria and the training procedures for exoskeletal-assisted walking and other mobility skills that can be progressed as the participant's skill level improves.
FAQs
Pattern-recognition receptors detect pathogens or their products and initiate immune signaling. This activation recruits and coordinates defensive responses through cytokines and other mediators. The same signaling can become harmful when it promotes excessive vascular leakage, cell death, or collateral tissue damage. Studying this transition helps explain why an immune response that begins protectively can impair organ function.
Cytokines coordinate immune defenses, helping organize responses against infectious threats. However, their effects can extend beyond pathogen control when inflammation becomes damaging to surrounding tissue. Increased mediator activity may contribute to vascular leakage and cell death, creating functional disruption within an organ. Measuring these opposing consequences is important for separating effective immunity from harmful inflammation.
Vascular leakage can disturb the local tissue environment, while cell death directly removes or damages structural components needed for normal organ function. Together, these effects can amplify the consequences of infection-driven inflammation beyond the initial pathogen encounter. Their presence provides mechanistic clues that immune activity is contributing to organ damage rather than only supporting pathogen defense.
Researchers compare evidence of immune defense with indicators of collateral damage and impaired organ function. Cytokine activity, vascular leakage, cell death, and biomarkers associated with disease severity can help reveal whether inflammation remains beneficial or has become harmful. This distinction is central to designing interventions that preserve antimicrobial defense while limiting persistent tissue injury.
Biomarkers can help indicate disease severity and support comparisons between protective immunity and damaging inflammation. In infection-related studies, they provide measurable evidence that links immune activity with the extent of organ disruption. Such information can help researchers evaluate disease progression, identify patients or experimental conditions associated with more severe outcomes, and assess responses to treatment strategies.
Mechanistic findings support two complementary therapeutic goals: controlling the infectious cause with antimicrobial treatments and reducing harmful immune effects with immunomodulatory therapies. Researchers can also investigate strategies that limit persistent damage and promote organ recovery. Applying these approaches requires preserving useful defense while preventing inflammation, vascular leakage, and cell death from continuing to impair tissue.