Ductal Stone Removal

Ductal stone removal is a medical procedure used to clear calculi that obstruct ducts and interfere with the normal flow of bodily fluids. Depending on the duct involved, clinicians may locate the stone with imaging or endoscopy, then extract it directly, fragment it with lithotripsy, or flush it out through controlled irrigation. Removing the obstruction can relieve pain, restore drainage, and reduce the risk of infection, inflammation, and tissue damage. The technique supports care across several medical specialties, including gastroenterology, urology, and otolaryngology, while advances in minimally invasive instruments continue to improve precision, recovery time, and patient outcomes.

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Research

JoVE EoE - Pancreatic Cancer

Acinar-to-Ductal Metaplasia Induction: A Method to Study Acinar Cell to Ductal Cell Differentiation in 3D Ex Vivo Culture

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2023

This video describes the technique of differentiating pancreatic acinar cells to ductal cells in ex vivo 3D culture. This helps to understand the mechanisms regulating the acinar-to-ductal metaplasia (ADM), a key process in the early development of pancreatic cancer.

Education

JoVE Core - Civil Engineering

Quarrying of Stone

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2024

Quarrying is the process of extracting stone from a quarry, where specialized techniques are employed to remove large blocks of stone safely and efficiently. This process can involve controlled explosions or more precision-oriented methods such as cutting and drilling. One common method involves using a diamond belt saw to cut large blocks from the quarry face. These blocks can be about 50 feet long and 12 feet high. After the initial vertical cut, drilling is performed at the base of the block.

Stone Masonry

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2024

Stone masonry is a construction technique that uses individual stones to build structures and can be categorized into two main types: rubble and ashlar. Rubble masonry uses uneven, naturally shaped stones such as river rocks or fragments from quarries. This method often requires the mason to select and possibly shape each stone to fit the designated space, ensuring a proper build, even with irregular stone sizes and shapes. Ashlar masonry, on the other hand, employs uniformly cut stones that...

Types of Building Stone

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2024

Building stones, essential materials for construction, are extracted from natural rock deposits and processed into specific forms and dimensions suitable for various building applications. These stones are broadly classified into three types based on their geological formation: igneous, sedimentary, and metamorphic. Igneous rocks are formed from the solidification of magma or lava. An example is granite, known for its durability and resistance to weathering, making it ideal for parts of...

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

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2024

The present protocol describes the reprogramming of Pancreatic Ductal Adenocarcinoma (PDAC) and normal pancreatic ductal epithelial cells into induced pluripotent stem cells (iPSCs). We provide an optimized and detailed, step-by-step procedure, from preparing lentivirus to establishing stable iPSC lines.

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