Multimodal Ultrasound
Multimodal Ultrasound - Related Videos
06:33
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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Cited by 1 •
2013
This paper describes in-house procedures of constructing a preclinical multimodality phantom made of tissue-mimicking (TM) materials for quality assurance (QA) of tumor size measurement in animal imaging modalities such as ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI).
09:43
Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging
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Cited by 1 •
2025
Here, we describe a protocol to use in vivo four-dimensional ultrasound imaging and ex vivo mass spectrometry imaging to assess biomechanical and biomolecular alterations in the murine cardiovascular system. This technique is applied to analyze cardiac remodeling in surgically induced myocardial infarction and vascular changes in aging animals.
10:53
A Novel Application of Musculoskeletal Ultrasound Imaging
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Cited by 14 •
2013
We describe a new ultrasound-based vector tissue Doppler imaging technique to measure muscle contraction velocity, strain and strain rate with sub-millisecond temporal resolution during dynamic activities. This approach provides complementary measurements of dynamic muscle function and could lead to a better understanding of mechanisms underlying musculoskeletal disorders.
14:20
High-frequency Ultrasound Imaging of the Abdominal Aorta
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2023
Source: Amelia R. Adelsperger, Evan H. Phillips, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana High-frequency ultrasound systems are used to acquire high resolution images. Here, the use of a state-of-the-art system will be demonstrated to image the morphology and hemodynamics of small pulsatile arteries and veins found in mice and rats. Ultrasound is a relatively inexpensive, portable, and versatile method for the noninvasive...
09:00
Murine Echocardiography and Ultrasound Imaging
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Cited by 61 •
2010
This video demonstrates use of a rail-mounted high-frequency ultrasound probe to perform echocardiography on an anesthetized mouse. The methods describe both conventional two-dimensional and M-mode measurements of cardiac function in addition to newer, more powerful tools such as color Doppler, strain analysis, as well as general and targeted contrast imaging.
FAQs
Its value lies in combining different physical signals rather than treating every finding as a structural abnormality. B-mode supplies anatomy, Doppler adds information about moving blood, elastography contributes tissue-stiffness estimates, and contrast-enhanced ultrasound reflects perfusion through microbubbles. Considering these outputs together can characterize a lesion or organ more comprehensively than any one signal alone.
Each mode answers a different clinical question. B-mode shows reflected sound-wave structure; Doppler detects frequency shifts associated with blood motion; elastography estimates how mechanically stiff tissue is; and contrast-enhanced ultrasound follows microbubble-enhanced perfusion. Their outputs are complementary, linking morphology with vascular behavior, stiffness, and perfusion instead of relying on anatomy alone.
Compared with a single-mode examination, the combined approach broadens the information available during assessment. Structural appearance can be considered alongside blood-flow, stiffness, and perfusion findings, which may reveal different aspects of the same lesion or organ. This wider characterization supports diagnosis, treatment planning, and monitoring while retaining ultrasound’s advantage of avoiding ionizing radiation.
Multimodal ultrasound can be applied in liver, breast, cardiovascular, and musculoskeletal imaging. The relevant combination of structural, flow, stiffness, and perfusion information helps characterize findings across these settings. Because the approach can support diagnosis, treatment planning, and monitoring, its role extends beyond initial detection to evaluating a condition and following changes over time.
Before treatment, integrated findings can contribute to planning by showing more than anatomy alone. During follow-up, the same range of signals can support monitoring, allowing structural appearance to be considered with blood flow, tissue stiffness, and perfusion. The examination therefore provides a broader basis for assessing lesions or organs across different clinical stages.
In medicine, this approach is relevant when clinicians need several complementary characteristics from an examination rather than a single structural view. It can assess anatomy, vascular motion, mechanical stiffness, and microbubble-tracked perfusion in one ultrasound-based assessment. Its ability to avoid ionizing radiation further supports its use in diagnostic evaluation, planning, and monitoring.