Kostas Kostarelos

Nanomedicine Lab, University of Manchester

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 19	2013

Other Publications

Article	Year
Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science. Advances in colloid and interface science\| PubMed ID: 14672846	2003
Binding and interstitial penetration of liposomes within avascular tumor spheroids. International journal of cancer. Journal international du cancer\| PubMed ID: 15382056	2004
Functionalized carbon nanotubes for plasmid DNA gene delivery. Angewandte Chemie (International ed. in English)\| PubMed ID: 15455428	2004
Liposome-mediated radiotherapeutics within avascular tumor spheroids: comparative dosimetry study for various radionuclides, liposome systems, and a targeting antibody. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 15632038	2005
Light-sensitive fusion between polymer-coated liposomes following physical anchoring of polymerisable polymers onto lipid bilayers by self-assembly. Faraday discussions\| PubMed ID: 15658785	2005
Biomedical applications of functionalised carbon nanotubes. Chemical communications (Cambridge, England)\| PubMed ID: 15672140	2005
Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. Journal of the American Chemical Society\| PubMed ID: 15783221	2005
Internal microdosimetry for single cells in radioimmunotherapy of B-cell lymphoma. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 15869460	2005
Synthesis and application of integrin targeting lipopeptides in targeted gene delivery. Chembiochem : a European journal of chemical biology\| PubMed ID: 15937988	2005
Engineering lipid vesicles of enhanced intratumoral transport capabilities: correlating liposome characteristics with penetration into human prostate tumor spheroids. Journal of liposome research\| PubMed ID: 16194925	2005
Applications of carbon nanotubes in drug delivery. Current opinion in chemical biology\| PubMed ID: 16233988	2005
Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors. Chemical Society reviews\| PubMed ID: 16239997	2005
What role can chemistry play in cationic liposome-based gene therapy research today? Advances in genetics\| PubMed ID: 16240991	2005
What Role Can Chemistry Play in Cationic Liposome-Based Gene Therapy Research Today? Advances in genetics\| PubMed ID: 16243061	2005
Carbon nanotubes: on the road to deliver. Current drug delivery\| PubMed ID: 16305427	2005
Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochimica et biophysica acta\| PubMed ID: 16307724	2006
Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16492781	2006
Double functionalization of carbon nanotubes for multimodal drug delivery. Chemical communications (Cambridge, England)\| PubMed ID: 16518484	2006
Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Advanced drug delivery reviews\| PubMed ID: 17113677	2006
Construction of nanoscale multicompartment liposomes for combinatory drug delivery. International journal of pharmaceutics\| PubMed ID: 17223294	2007
Single-cell dosimetry for radioimmunotherapy of B-cell lymphoma patients with special reference to leukemic spread. Cancer biotherapy & radiopharmaceuticals\| PubMed ID: 17651041	2007
Establishing nanomedicine. Nanomedicine (London, England)\| PubMed ID: 17716156	2006
Liposome-nanoparticle hybrids for multimodal diagnostic and therapeutic applications. Nanomedicine (London, England)\| PubMed ID: 17716195	2007
The emergence of nanomedicine: a field in the making. Nanomedicine (London, England)\| PubMed ID: 17716200	2006
Multifunctionalised cationic fullerene adducts for gene transfer: design, synthesis and DNA complexation. Chemical communications (Cambridge, England)\| PubMed ID: 17851620	2007
Functionalized carbon nanotubes in drug design and discovery. Accounts of chemical research\| PubMed ID: 17867649	2008
Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Chemical communications (Cambridge, England)\| PubMed ID: 18188467	2008
Opportunities and challenges of carbon-based nanomaterials for cancer therapy. Expert opinion on drug delivery\| PubMed ID: 18318654	2008
Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine (London, England)\| PubMed ID: 18373422	2008
Hype around nanotubes creates unrealistic hopes. Nature\| PubMed ID: 18480788	2008
Artificial envelopment of nonenveloped viruses: enhancing adenovirus tumor targeting in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18556649	2008
The long and short of carbon nanotube toxicity. Nature biotechnology\| PubMed ID: 18612299	2008
Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nature nanotechnology\| PubMed ID: 18654229	2007
Carbon-nanotube shape and individualization critical for renal excretion. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18666166	2008
Functionalized-quantum-dot-liposome hybrids as multimodal nanoparticles for cancer. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 18711753	2008
Synthesis and analysis of novel glycerolipids for the treatment of metabolic syndrome. Journal of medicinal chemistry\| PubMed ID: 19175322	2009
Nanoengineering artificial lipid envelopes around adenovirus by self-assembly. ACS nano\| PubMed ID: 19206502	2008
Lipid-quantum dot bilayer vesicles enhance tumor cell uptake and retention in vitro and in vivo. ACS nano\| PubMed ID: 19206564	2008
Designer adenoviruses for nanomedicine and nanodiagnostics. Trends in biotechnology\| PubMed ID: 19251331	2009
Antitumor activity and prolonged survival by carbon-nanotube-mediated therapeutic siRNA silencing in a human lung xenograft model. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19306454	2009
Synthesis and characterization of a carbon nanotube-dendron series for efficient siRNA delivery. Journal of the American Chemical Society\| PubMed ID: 19555104	2009
Blood circulation and tissue biodistribution of lipid--quantum dot (L-QD) hybrid vesicles intravenously administered in mice. Bioconjugate chemistry\| PubMed ID: 19655725	2009
Tumor targeting of functionalized quantum dot-liposome hybrids by intravenous administration. Molecular pharmaceutics\| PubMed ID: 19718803	2009
Nanoparticles functionalized with recombinant single chain Fv antibody fragments (scFv) for the magnetic resonance imaging of cancer cells. Biomaterials\| PubMed ID: 19889453	2010
Chapter 17 - Engineering cationic liposome siRNA complexes for in vitro and in vivo delivery. Methods in enzymology\| PubMed ID: 19903563	2009
Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20150514	2010
Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers. Chemical communications (Cambridge, England)\| PubMed ID: 20162159	2010
Functionalized carbon nanotubes for probing and modulating molecular functions. Chemistry & biology\| PubMed ID: 20189101	2010
Nanorobots for medicine: how close are we? Nanomedicine (London, England)\| PubMed ID: 20394527	2010
Assessment of cellular uptake and cytotoxicity of carbon nanotubes using flow cytometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20422386	2010
Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. Nature materials\| PubMed ID: 20473287	2010
Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. Chemical communications (Cambridge, England)\| PubMed ID: 20830345	2010
Carbon nanotubes: Fibrillar pharmacology. Nature materials\| PubMed ID: 20864939	2010
Hybrid polymer-grafted multiwalled carbon nanotubes for in vitro gene delivery. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 20878655	2010
Physiologically based pharmacokinetic modeling of nanoparticles. ACS nano\| PubMed ID: 20945925	2010
Intracellular trafficking and gene expression of pH-sensitive, artificially enveloped adenoviruses in vitro and in vivo. Biomaterials\| PubMed ID: 21269689	2011
Doxorubicin-loaded lipid-quantum dot hybrids: surface topography and release properties. International journal of pharmaceutics\| PubMed ID: 21315141	2011
Cytotoxic assessment of carbon nanotube interaction with cell cultures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21424457	2011
Cellular uptake mechanisms of functionalised multi-walled carbon nanotubes by 3D electron tomography imaging. Nanoscale\| PubMed ID: 21603701	2011
Antibody covalent immobilization on carbon nanotubes and assessment of antigen binding. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21608125	2011
Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. The American journal of pathology\| PubMed ID: 21641383	2011
Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21690348	2011
Making carbon nanotubes biocompatible and biodegradable. Chemical communications (Cambridge, England)\| PubMed ID: 21776531	2011
Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Accounts of chemical research\| PubMed ID: 21812415	2011
Cellular uptake and cytotoxic impact of chemically functionalized and polymer-coated carbon nanotubes. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 21919194	2011
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22084097	2011
Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake. Nanomedicine (London, England)\| PubMed ID: 22122583	2011
Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes. Biomaterials\| PubMed ID: 22289266	2012
Targeting carbon nanotubes against cancer. Chemical communications (Cambridge, England)\| PubMed ID: 22428156	2012
Pharmacokinetics & tissue distribution of temperature-sensitive liposomal doxorubicin in tumor-bearing mice triggered with mild hyperthermia. Biomaterials\| PubMed ID: 22459195	2012
Therapeutics, imaging and toxicity of nanomaterials in the central nervous system. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22512901	2012
Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks. Archives of toxicology\| PubMed ID: 22547313	2012
Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. Angewandte Chemie (International ed. in English)\| PubMed ID: 22623333	2012
In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex. Nanomedicine (London, England)\| PubMed ID: 22712575	2012
The alluring potential of functionalized carbon nanotubes in drug discovery. Expert opinion on drug discovery\| PubMed ID: 22823208	2010
Liposome-gold nanorod hybrids for high-resolution visualization deep in tissues. Journal of the American Chemical Society\| PubMed ID: 22852749	2012
Lipid-peptide vesicle nanoscale hybrids for triggered drug release by mild hyperthermia in vitro and in vivo. ACS nano\| PubMed ID: 22857653	2012
A high poly(ethylene glycol) density on graphene nanomaterials reduces the detachment of lipid-poly(ethylene glycol) and macrophage uptake. Acta biomaterialia\| PubMed ID: 22995407	2013
The effect of artificial lipid envelopment of Adenovirus 5 (Ad5) on liver de-targeting and hepatotoxicity. Biomaterials\| PubMed ID: 23146432	2013
Safety considerations for graphene: lessons learnt from carbon nanotubes. Accounts of chemical research\| PubMed ID: 23163827	2013
Purified graphene oxide dispersions lack in vitro cytotoxicity and in vivo pathogenicity. Advanced healthcare materials\| PubMed ID: 23184580	2013
Electroresponsive polymer-carbon nanotube hydrogel hybrids for pulsatile drug delivery in vivo. Advanced healthcare materials\| PubMed ID: 23184678	2013
Asbestos-like pathogenicity of long carbon nanotubes alleviated by chemical functionalization. Angewandte Chemie (International ed. in English)\| PubMed ID: 23319294	2013
In vivo cell reprogramming towards pluripotency by virus-free overexpression of defined factors. PloS one\| PubMed ID: 23355895	2013
The effective nuclear delivery of doxorubicin from dextran-coated gold nanoparticles larger than nuclear pores. Biomaterials\| PubMed ID: 23395274	2013
Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery. Autophagy\| PubMed ID: 23422759	2013
Prospects and challenges of graphene in biomedical applications. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 23494834	2013
Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo. ACS nano\| PubMed ID: 23527750	2013
Pulmonary DWCNT exposure causes sustained local and low-level systemic inflammatory changes in mice. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V\| PubMed ID: 23542608	2013
Ammonium and Guanidinium Dendron-Carbon Nanotubes by Amidation and Click Chemistry and their Use for siRNA Delivery. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 23650276	2013
How do functionalized carbon nanotubes land on, bind to and pierce through model and plasma membranes. Nanoscale\| PubMed ID: 24056765	2013
Pharmacology of carbon nanotubes: Toxicokinetics, excretion and tissue accumulation. Advanced drug delivery reviews\| PubMed ID: 24184372	2013
Carbon nanotubes as vectors for gene therapy: Past achievements, present challenges and future goals. Advanced drug delivery reviews\| PubMed ID: 24184373	2013
Carbon nanotubes in medicine and biology - Safety and toxicology. Advanced drug delivery reviews\| PubMed ID: 24211669	2013
Hemotoxicity of carbon nanotubes. Advanced drug delivery reviews\| PubMed ID: 24211768	2013
Carbon nanotubes in medicine & biology - Therapy and diagnostics. Advanced drug delivery reviews\| PubMed ID: 24220279	2013
Functionalized carbon nanotubes in the brain: cellular internalization and neuroinflammatory responses. PloS one\| PubMed ID: 24260521	2013