Fabio Cominelli

Division of Gastroenterology, Case Western Reserve University School of Medicine, Cleveland

Affiliated withCase Western Reserve University School of Medicine, Cleveland Case Western Reserve University

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 51	2013
Publication title Cited by 7	2017

Other Publications

Article	Year
Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure. Gastroenterology\| PubMed ID: 11832463	2002
A possible role of IL-1ra 3'-untranslated region in modulation of protein production. Cytokine\| PubMed ID: 11886177	2002
Effect of misoprostol on ibuprofen-induced renal dysfunction in patients with decompensated cirrhosis: results of a double-blind placebo-controlled parallel group study. The American journal of gastroenterology\| PubMed ID: 12190173	2002
Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12391251	2002
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. The Journal of experimental medicine\| PubMed ID: 12486099	2002
Emergence of perianal fistulizing disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis. Gastroenterology\| PubMed ID: 12671894	2003
Mouse models for the study of Crohn's disease. Trends in molecular medicine\| PubMed ID: 12763527	2003
TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of intestinal epithelial cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12832622	2003
Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc. Gastroenterology\| PubMed ID: 12891551	2003
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14568967	2003
Future therapies for inflammatory bowel disease. Current gastroenterology reports\| PubMed ID: 14602063	2003
The Th1 immune pathway as a therapeutic target in Crohn's disease. Current opinion in investigational drugs (London, England : 2000)\| PubMed ID: 14758766	2003
Effect of digestive health care services integration on resource use and outcomes in patients with digestive disorders. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 15017507	2003
Optimal dosing of 5-aminosalicylic acid: 5 decades of choosing between politicians. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 15017510	2003
Differential contribution of IL-1Ra isoforms to allele-specific IL-1Ra mRNA accumulation. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 15144571	2004
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. The Journal of clinical investigation\| PubMed ID: 15286805	2004
Cytokine-based therapies for Crohn's disease--new paradigms. The New England journal of medicine\| PubMed ID: 15537904	2004
Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease. Gastroenterology\| PubMed ID: 15685547	2005
L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15699171	2005
Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology\| PubMed ID: 15765401	2005
Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice. The American journal of pathology\| PubMed ID: 15793286	2005
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology\| PubMed ID: 16012931	2005
New concepts in the pathophysiology of inflammatory bowel disease. Annals of internal medicine\| PubMed ID: 16365470	2005
Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease. Gastroenterology\| PubMed ID: 16401463	2006
The primary defect in experimental ileitis originates from a nonhematopoietic source. The Journal of experimental medicine\| PubMed ID: 16505137	2006
Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis. The Journal of experimental medicine\| PubMed ID: 16567389	2006
Role of TL1A and its receptor DR3 in two models of chronic murine ileitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16698931	2006
Novel strategies to attenuate immune activation in Crohn's disease. Current opinion in pharmacology\| PubMed ID: 16753341	2006
Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association\| PubMed ID: 16829206	2006
Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. The Journal of clinical investigation\| PubMed ID: 17024245	2006
Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology\| PubMed ID: 17101325	2006
Cytokine therapy for Crohn's disease: advances in translational research. Annual review of medicine\| PubMed ID: 17217333	2007
Commensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17237431	2007
The attrition of young physician-scientists: problems and potential solutions. Gastroenterology\| PubMed ID: 17258744	2007
Cloning IL-1 and the birth of a new era in cytokine biology. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17442919	2007
Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. Gastroenterology\| PubMed ID: 17498517	2007
Immunopathogenesis of inflammatory bowel disease: current concepts. Current opinion in gastroenterology\| PubMed ID: 17545770	2007
Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17982092	2007
MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 18032482	2008
A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18250468	2008
Early and late gut immune responses in IBD. Journal of pediatric gastroenterology and nutrition\| PubMed ID: 18354325	2008
Innate and adaptive immune responses related to IBD pathogenesis. Current gastroenterology reports\| PubMed ID: 18377804	2007
Commensal bacteria and "oncologic surveillance": suggestions from an experimental model. Journal of clinical gastroenterology\| PubMed ID: 18685507	2008
AGA Institute Future Trends Committee report: the future of gastroenterology training programs in the United States. Gastroenterology\| PubMed ID: 19009690	2008
Emerging drugs for the treatment of ulcerative colitis. Expert opinion on emerging drugs\| PubMed ID: 19656075	2009
Probiotics promote gut health through stimulation of epithelial innate immunity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20018654	2010
Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20926792	2010
SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis. Inflammatory bowel diseases\| PubMed ID: 21557393	2011
Spontaneous, immune-mediated gastric inflammation in SAMP1/YitFc mice, a model of Crohn's-like gastritis. Gastroenterology\| PubMed ID: 21704001	2011
A multicenter retrospective experience of infliximab in Crohn's disease patients: infusion reaction rates and treatment persistency. Gastroenterology & hepatology\| PubMed ID: 21960854	2007
New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation. Cytokine\| PubMed ID: 22795953	2012
Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism. PloS one\| PubMed ID: 22848704	2012
Vercirnon for the treatment of Crohn's disease. Expert opinion on investigational drugs\| PubMed ID: 23627683	2013
RIP2 activity in inflammatory disease and implications for novel therapeutics. Journal of leukocyte biology\| PubMed ID: 23794710	2013
Inhibition of leukocyte trafficking in inflammatory bowel disease. The New England journal of medicine\| PubMed ID: 23964940	2013
Intestinal-Specific TNFÎ± Overexpression Induces Crohn's-Like Ileitis in Mice. PloS one\| PubMed ID: 23977323	2013
Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24082103	2013
The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation. Current opinion in gastroenterology\| PubMed ID: 24100723	2013
Functional defects in NOD2 signaling in experimental and human Crohn disease. Gut microbes\| PubMed ID: 24637801	2014
Inflammatory bowel disease. Immunology letters\| PubMed ID: 24938525	2014
Occurrence of spontaneous periodontal disease in the SAMP1/YitFc murine model of Crohn disease. Journal of periodontology\| PubMed ID: 25019175	2014
The dual role of nod-like receptors in mucosal innate immunity and chronic intestinal inflammation. Frontiers in immunology\| PubMed ID: 25071778	2014
Cytokines and mucosal immunity. Current opinion in gastroenterology\| PubMed ID: 25203451	2014
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. The Journal of biological chemistry\| PubMed ID: 25213858	2014
Safety considerations when using anti-TNFα therapy to treat Crohn's disease. Expert opinion on drug safety\| PubMed ID: 25400161	2015
Ulcerative Colitis: What is the Optimal Treatment Goal and How Do We Achieve It? Current treatment options in gastroenterology\| PubMed ID: 25619458	2015
SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration. Gastroenterology\| PubMed ID: 25620669	2015
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. Science (New York, N.Y.)\| PubMed ID: 26068857	2015
Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes. Nature communications\| PubMed ID: 26154811	2015
Dysregulated intrahepatic CD4(+) T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 26213712	2015
Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis. Inflammatory bowel diseases\| PubMed ID: 26348447	2015
Role of type 2 immunity in intestinal inflammation. Current opinion in gastroenterology\| PubMed ID: 26376478	2015
Pathway-based approaches to the treatment of inflammatory bowel disease. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 26408803	2016
IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis. The American journal of pathology\| PubMed ID: 26908008	2016
Colitis-Associated and Sporadic Colon Cancers: Different Diseases, Different Mutations? Gastroenterology\| PubMed ID: 26924087	2016
A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27233964	2016
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Frontiers in immunology\| PubMed ID: 27531998	2016
Clinical Effects of Gamma-Radiation-Resistant Aspergillus sydowii on Germ-Free Mice Immunologically Prone to Inflammatory Bowel Disease. Journal of pathogens\| PubMed ID: 27630775	2016
Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis. Cancer research\| PubMed ID: 27634763	2016
Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. Gastroenterology\| PubMed ID: 27639802	2017
Cytokines and intestinal inflammation. Current opinion in gastroenterology\| PubMed ID: 27673380	2016
Our Vision for the Future of Inflammatory Bowel Diseases: Research, Innovations, and Controversies. Inflammatory bowel diseases\| PubMed ID: 28002124	2017
Mesenchymal stem/stromal cell therapy for inflammatory bowel disease: an updated review with maintenance of remission. Current opinion in gastroenterology\| PubMed ID: 28134690	2017
Epithelial-specific Toll-like Receptor (TLR)5 Activation Mediates Barrier Dysfunction in Experimental Ileitis. Inflammatory bowel diseases\| PubMed ID: 28146004	2017
A novel model of colitis-associated cancer in SAMP1/YitFc mice with Crohn's disease-like ileitis. PloS one\| PubMed ID: 28301579	2017
Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model? Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28560286	2017
A guiding map for inflammation. Nature immunology\| PubMed ID: 28722720	2017