designing-silk-silk-protein-alloy-materials-for-biomedical

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Fibrous proteins display different sequences and structures that have been used for various applications in biomedical fields such as biosensors, ...

Rowan University

Cooper Medical School of Rowan University

The endogenous opioid system plays an important role in cognitive functions and may also contribute to the progression of some kind of dementia. Naloxone has been shown to exert beneficial effects on memory deficits in patients with senile dementia and reverse some of the effects induced by endogeneous opioids. We therefore investigated the effects of naloxone on cognitive function in rats with vascular dementia (VD).

Effect of naloxone on cognitive function in vascular dementia in rats.

Previous studies have shown that phenytoin can protect hippocampal structure from damage by chronic stress, while whether it can reverse the hippocampal malfunction induced by chronic stress is unknown. We investigated the effects of phenytoin on motor activity of stressed rats and on the long-term memory of water maze spatial training, which is known to depend on hippocampal function. We also explored whether phenytoin could protect long-term potentiation (LTP) in hippocampal CA1 region from depression of chronic stressed rats. Isolated hippocampal slices of rats were used to observe the changes of LTP in hippocampal CA1 field with electrophysiological technique. The results showed that the motor activity of chronic forced-swimming rats was markedly higher than that of control rats, and phenytoin could not affect this change. The performance of water maze spatial training indicated that chronic stress damages long-term memory but not short-term memory, and phenytoin could reverse this long-term memory deficit. The increases of LTP after HFS in control and stress-phenytoin groups were significantly greater than those in stress-saline group (P < 0.05). There were no significant differences between control group and stress-phenytoin group (P > 0.05) and between control and control-phenytoin groups (P > 0.05). These findings provided the first evidence with behavioral and electrophysiological technique that phenytoin could reverse the hippocampal-dependent memory deficit and depression of LTP induced by chronic stress, which may be helpful for exploring the pathogenesis and improving the therapy of depression.

Phenytoin reverses the chronic stress-induced impairment of memory consolidation for water maze training and depression of LTP in rat hippocampal CA1 region, but does not affect motor activity.

Article	Year
Effect of naloxone on cognitive function in vascular dementia in rats. The Indian journal of medical research\| PubMed ID: 12440200	2002
Phenytoin reverses the chronic stress-induced impairment of memory consolidation for water maze training and depression of LTP in rat hippocampal CA1 region, but does not affect motor activi... Brain research. Cognitive brain research\| PubMed ID: 16099351	2005

Xiao Hu

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