Geoff H. Werstuck

Department of Biochemistry and Biomedical Sciences, McMaster University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 51	2013

Other Publications

Article	Year
Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion. The Journal of biological chemistry\| PubMed ID: 12370193	2002
Overexpression of the 78-kDa glucose-regulated protein/immunoglobulin-binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity. The Journal of biological chemistry\| PubMed ID: 12621026	2003
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. The Journal of biological chemistry\| PubMed ID: 12738777	2003
Hyperhomocysteinemia and its role in the development of atherosclerosis. Clinical biochemistry\| PubMed ID: 12951169	2003
Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice. Circulation\| PubMed ID: 15210586	2004
Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. Bioorganic & medicinal chemistry letters\| PubMed ID: 15482904	2004
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3. Journal of cell science\| PubMed ID: 15585578	2005
Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes\| PubMed ID: 16380481	2006
Mechanisms linking diabetes mellitus to the development of atherosclerosis: a role for endoplasmic reticulum stress and glycogen synthase kinase-3. Canadian journal of physiology and pharmacology\| PubMed ID: 16845889	2006
Induction of GRP78 by valproic acid is dependent upon histone deacetylase inhibition. Bioorganic & medicinal chemistry letters\| PubMed ID: 17566732	2007
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2. The international journal of biochemistry & cell biology\| PubMed ID: 17604677	2007
Diabetes and cardiovascular disease: explaining the relationship. Reviews in cardiovascular medicine\| PubMed ID: 17938614	2007
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18364397	2008
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion... The American journal of pathology\| PubMed ID: 19095952	2009
Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model. Antioxidants & redox signaling\| PubMed ID: 19548776	2009
Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 19952345	2010
Diabetes, hyperglycemia and accelerated atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling. Cardiovascular & hematological disorders drug targets\| PubMed ID: 20350283	2010
Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells. Obesity (Silver Spring, Md.)\| PubMed ID: 21633399	2012
Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE-/- mice. Atherosclerosis\| PubMed ID: 21855875	2011
Endoplasmic reticulum stress and glycogen synthase kinase-3Î² activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 21998135	2012
The role of glucosamine-induced ER stress in diabetic atherogenesis. Experimental diabetes research\| PubMed ID: 22474416	2012
Leptin promotes osteoblast differentiation and mineralization of primary cultures of vascular smooth muscle cells by inhibiting glycogen synthase kinase (GSK)-3β. Biochemical and biophysical research communications\| PubMed ID: 22906741	2012
Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T. Biochimica et biophysica acta\| PubMed ID: 23747341	2013
The development and progression of atherosclerosis: evidence supporting a role for endoplasmic reticulum (ER) stress signaling. Cardiovascular & hematological disorders drug targets\| PubMed ID: 23988003	2013