Sridhar Mani

Department of Genetics, albert einstein college of medicine

Affiliated withalbert einstein college of medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2013

Other Publications

Article	Year
Tyrosine kinase inhibitors: a clinical perspective. Current oncology reports\| PubMed ID: 11734109	2002
Oxaliplatin: a review of evolving concepts. Cancer investigation\| PubMed ID: 11901545	2002
Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advan... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11948111	2002
Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil. Cancer chemotherapy and pharmacology\| PubMed ID: 11976834	2002
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12114401	2002
Phase I clinical trial of irinotecan with oral capecitabine in patients with gastrointestinal and other solid malignancies. American journal of clinical oncology\| PubMed ID: 12393999	2002
Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling p... Molecular cancer therapeutics\| PubMed ID: 12479366	2002
Phase 1 dose escalation study of docetaxel with filgrastim support in patients with advanced solid tumors. Medical oncology (Northwood, London, England)\| PubMed ID: 12665678	2003
A pilot study of edrecolomab (Panorex, 17-1A antibody) and capecitabine in patients with advanced or metastatic adenocarcinoma. Cancer investigation\| PubMed ID: 12743982	2003
The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. Current medicinal chemistry. Anti-cancer agents\| PubMed ID: 12769779	2003
A phase II study of rebeccamycin analog NSC 655649 in patients with metastatic colorectal cancer. Investigational new drugs\| PubMed ID: 12795535	2003
Current approaches to novel therapeutics in pancreatic cancer. Investigational new drugs\| PubMed ID: 12795537	2003
Erlotinib (Tarceva): a promising drug targeting epidermal growth factor receptor tyrosine kinase. Expert review of anticancer therapy\| PubMed ID: 12820772	2003
Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12860942	2003
A safety study of a mixed-backbone oligonucleotide (GEM231) targeting the type I regulatory subunit alpha of protein kinase A using a continuous infusion schedule in patients with refractory... Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14519628	2003
Pharmacology of oxaliplatin in solid tumor patients with hepatic dysfunction: a preliminary report of the National Cancer Institute Organ Dysfunction Working Group. Seminars in oncology\| PubMed ID: 14523790	2003
Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the national cancer institute organ dysfunction working group. Seminars in oncology\| PubMed ID: 14523791	2003
TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 14726502	2004
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14977827	2004
9-Aminocamptothecin (9-AC) given as a 120-hour continuous infusion in patients with advanced adenocarcinomas of the stomach and gastroesophageal junction: A phase II trial of the University ... Investigational new drugs\| PubMed ID: 15122080	2004
The clinical development of new mitotic inhibitors that stabilize the microtubule. Anti-cancer drugs\| PubMed ID: 15205596	2004
UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines. Journal of neurochemistry\| PubMed ID: 15255949	2004
Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors. Investigational new drugs\| PubMed ID: 15292715	2004
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital. Clinical pharmacology and therapeutics\| PubMed ID: 15536463	2004
A Phase II trial of fixed dose rate gemcitabine in patients with advanced biliary tree carcinoma. American journal of clinical oncology\| PubMed ID: 15577433	2004
Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancer. Cancer chemotherapy and pharmacology\| PubMed ID: 15895230	2005
A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines. Investigational new drugs\| PubMed ID: 16012789	2005
Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers. Cancer chemotherapy and pharmacology\| PubMed ID: 16133531	2006
Phase II trials of dolastatin-10 in advanced pancreaticobiliary cancers. Investigational new drugs\| PubMed ID: 16133801	2005
Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16144941	2005
Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors. Cancer chemotherapy and pharmacology\| PubMed ID: 16205924	2006
Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes. Investigational new drugs\| PubMed ID: 16505951	2006
A phase I safety and dose escalation trial of docetaxel combined with GEM231, a second generation antisense oligonucleotide targeting protein kinase A R1alpha in patients with advanced solid... Investigational new drugs\| PubMed ID: 16683205	2006
Phase II study of mitomycin-C, adriamycin, cisplatin (MAP) and Bleomycin-CCNU in patients with advanced cancer of the anal canal: An eastern cooperative oncology group study E7282. Investigational new drugs\| PubMed ID: 16763788	2006
Phase II trial of nolatrexed dihydrochloride [Thymitaq, AG 337] in patients with advanced hepatocellular carcinoma. Investigational new drugs\| PubMed ID: 16957834	2007
Autoantibody cancer biomarker: extracellular protein kinase A. Cancer research\| PubMed ID: 16982736	2006
Pharmacokinetic and safety study of weekly irinotecan and oral capecitabine in patients with advanced solid cancers. Investigational new drugs\| PubMed ID: 17195945	2007
Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17317836	2007
Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17438109	2007
Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17575231	2007
Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites. Molecular pharmacology\| PubMed ID: 17576789	2007
Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17699862	2007
The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 18096694	2008
Rhabdoid tumor growth is inhibited by flavopiridol. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18223228	2008
Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: a study by the National Cancer Institute Organ Dysfunc... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18235116	2008
Agranulocytosis induced by nonchemotherapy drugs. Annals of internal medicine\| PubMed ID: 18283213	2008
The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18451235	2008
Computational discovery of novel low micromolar human pregnane X receptor antagonists. Molecular pharmacology\| PubMed ID: 18579710	2008
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bioorganic & medicinal chemistry letters\| PubMed ID: 18583127	2008
Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18765524	2008
Novel orphan nuclear receptors-coregulator interactions controlling anti-cancer drug metabolism. Current drug metabolism\| PubMed ID: 18781912	2008
A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18981010	2008
The efficacy and safety of ixabepilone monotherapy in the treatment of breast and gynecologic malignancies. Expert opinion on drug safety\| PubMed ID: 19236220	2009
Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions. Expert opinion on drug metabolism & toxicology\| PubMed ID: 19239394	2009
Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharmaceutical research\| PubMed ID: 19415465	2009
A phase I study of eribulin mesylate (E7389), a mechanistically novel inhibitor of microtubule dynamics, in patients with advanced solid malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19509177	2009
Design, synthesis and biological evaluation of 2H-benzo[b][1,4] oxazine derivatives as hypoxia targeted compounds for cancer therapeutics. Bioorganic & medicinal chemistry letters\| PubMed ID: 19515559	2009
Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors. Investigational new drugs\| PubMed ID: 19572105	2010
Phase II study of paclitaxel plus the protein kinase C inhibitor bryostatin-1 in advanced pancreatic carcinoma. American journal of clinical oncology\| PubMed ID: 19738452	2010
Orphan nuclear receptors as targets for drug development. Pharmaceutical research\| PubMed ID: 20372994	2010
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database. Environmental health perspectives\| PubMed ID: 20558333	2010
Induction of CYP3A4 by vinblastine: Role of the nuclear receptor NR1I2. The Annals of pharmacotherapy\| PubMed ID: 20959500	2010
Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.)\| PubMed ID: 21051639	2010
Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC cancer\| PubMed ID: 21092078	2010
Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. Biochemical and biophysical research communications\| PubMed ID: 21329659	2011
Post-translational modification of pregnane x receptor. Pharmacological research : the official journal of the Italian Pharmacological Society\| PubMed ID: 21397695	2011
In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. Molecular pharmacology\| PubMed ID: 21464197	2011
Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study. Cancer chemotherapy and pharmacology\| PubMed ID: 21479634	2011
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. The Journal of clinical investigation\| PubMed ID: 21747170	2011
Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors. Cancer chemotherapy and pharmacology\| PubMed ID: 21874318	2012
Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochemical pharmacology\| PubMed ID: 21920351	2011
Sixth International Congress on Shwachman-Diamond syndrome: from patients to genes and back. Annals of the New York Academy of Sciences\| PubMed ID: 22191554	2011
Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: phase I NCI Organ Dysfunction Working Group Study NCI-6432. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22394984	2012
Safety, pharmacokinetics, and activity of EZN-2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies. Cancer\| PubMed ID: 22674635	2012
Alleviation of gut inflammation by Cdx2/Pxr pathway in a mouse model of chemical colitis. PloS one\| PubMed ID: 22815676	2012
Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response. Cancer letters\| PubMed ID: 22939994	2013
PXR antagonists and implication in drug metabolism. Drug metabolism reviews\| PubMed ID: 23330542	2013
Methodologies to decipher the cell secretome. Biochimica et biophysica acta\| PubMed ID: 23376189	2013
Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling. The British journal of nutrition\| PubMed ID: 23506745	2013
Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. The Journal of biological chemistry\| PubMed ID: 23525103	2013
Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 23536316	2013
Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis. Current drug targets\| PubMed ID: 23597015	2013
Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular pharmacology\| PubMed ID: 23690068	2013
Clinical outcome and prognostic markers for patients with gynecologic malignancies in phase 1 clinical trials: a single institution experience from 1999 to 2010. Gynecologic oncology\| PubMed ID: 23877015	2013
Understanding and Modulating Mammalian-Microbial Communication for Improved Human Health. Annual review of pharmacology and toxicology\| PubMed ID: 24160697	2013