Tom Mikkelsen

Department of Neurosurgery, Henry Ford Hospital

Research Area

Biography

Tom Mikkelsen has not added Biography.
If you are Tom Mikkelsen and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 43	2014

Other Publications

Article	Year
Studying the heterogeneity of brain tumors using medium throughput LOH analysis. Cytometry\| PubMed ID: 11774351	2002
Correlations between magnetic resonance spectroscopy and image-guided histopathology, with special attention to radiation necrosis. Neurosurgery\| PubMed ID: 12234397	2002
Degradation of extracellular matrix protein tenascin-C by cathepsin B: an interaction involved in the progression of gliomas. Biological chemistry\| PubMed ID: 12437133	2002
Angiogenesis in glioma: molecular mechanisms and roadblocks to translation. Cancer journal (Sudbury, Mass.)\| PubMed ID: 12952305	2003
Phase 2 study of weekly irinotecan in adults with recurrent malignant glioma: final report of NABTT 97-11. Neuro-oncology\| PubMed ID: 14769136	2004
Associations among magnetic resonance spectroscopy, apparent diffusion coefficients, and image-guided histopathology with special attention to radiation necrosis. Neurosurgery\| PubMed ID: 15113465	2004
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the ... Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 15509513	2004
Developing a brain tumor center. Journal of neuro-oncology\| PubMed ID: 15527088	2004
Assessment of brain tumor angiogenesis inhibitors using perfusion magnetic resonance imaging: quality and analysis results of a phase I trial. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 15558578	2004
Analysis of glioma cell platinum response by metacomparison of two-dimensional chromatographic proteome profiles. Molecular & cellular proteomics : MCP\| PubMed ID: 15951525	2006
SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer letters\| PubMed ID: 15967572	2006
Angiogenesis and apoptosis in glioma: two arenas for promising new therapies. Journal of cellular biochemistry\| PubMed ID: 16052525	2005
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma. Neuro-oncology\| PubMed ID: 16053699	2005
A quantitative model of tumor-induced angiogenesis in the nude mouse. Neurosurgery\| PubMed ID: 16094162	2005
AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma. Glia\| PubMed ID: 16518831	2006
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer cell\| PubMed ID: 16616334	2006
Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma. Neuro-oncology\| PubMed ID: 16723633	2006
Increased expression of thymidylate synthetase (TS), ubiquitin specific protease 10 (USP10) and survivin is associated with poor survival in glioblastoma multiforme (GBM). Journal of neuro-oncology\| PubMed ID: 16773218	2006
The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16951236	2006
High-resolution global genomic survey of 178 gliomas reveals novel regions of copy number alteration and allelic imbalances. Cancer research\| PubMed ID: 17018597	2006
Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme. Investigational new drugs\| PubMed ID: 17080256	2007
A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 17260000	2007
Proteomic comparison of oligodendrogliomas with and without 1pLOH. Cancer biology & therapy\| PubMed ID: 17264672	2007
2D/3D image fusion for accurate target localization and evaluation of a mask based stereotactic system in fractionated stereotactic radiotherapy of cranial lesions. Medical physics\| PubMed ID: 17278807	2006
Cerebellar tumors in pediatric patients: can they be differentiated using diffusion-weighted imaging? Nature clinical practice. Neurology\| PubMed ID: 17279080	2007
Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17470857	2007
Decrease of endogenous vascular endothelial growth factor may not affect glioma cell proliferation and invasion. Journal of experimental therapeutics & oncology\| PubMed ID: 17552362	2007
Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells. Biochemical and biophysical research communications\| PubMed ID: 17825796	2007
Altered adenosine-to-inosine RNA editing in human cancer. Genome research\| PubMed ID: 17908822	2007
First-pass perfusion computed tomography: initial experience in differentiating recurrent brain tumors from radiation effects and radiation necrosis. Neurosurgery\| PubMed ID: 17986939	2007
Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Molecular cancer research : MCR\| PubMed ID: 18184972	2008
FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia (New York, N.Y.)\| PubMed ID: 18320068	2008
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis. Neuro-oncology\| PubMed ID: 18403493	2008
Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma. Neuro-oncology\| PubMed ID: 18477765	2008
Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert opinion on investigational drugs\| PubMed ID: 18616418	2008
Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells. Journal of experimental & clinical cancer research : CR\| PubMed ID: 18647407	2008
Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease. Neuro-oncology\| PubMed ID: 18725460	2008
Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 18981465	2008
Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration. Neoplasia (New York, N.Y.)\| PubMed ID: 19048112	2008
Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. Journal of neuro-oncology\| PubMed ID: 19066727	2009
Bevacizumab and irinotecan treatment for progressive diffuse brainstem glioma: case report. Journal of neuro-oncology\| PubMed ID: 19139822	2009
Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis. Journal of neuro-oncology\| PubMed ID: 19189055	2009
Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency. International journal of cancer. Journal international du cancer\| PubMed ID: 19199360	2009
Odyssey of hope: a physician's guide to communicating with brain tumor patients across the continuum of care. Journal of neuro-oncology\| PubMed ID: 19357952	2009
The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. International journal of cancer. Journal international du cancer\| PubMed ID: 19431142	2009
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19636006	2009
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19720927	2009
Can permeability measurements add to blood volume measurements in differentiating tumefactive demyelinating lesions from high grade gliomas using perfusion CT? Journal of neuro-oncology\| PubMed ID: 19830525	2010
The role of salvage reirradiation for malignant gliomas that progress on bevacizumab. Journal of neuro-oncology\| PubMed ID: 19838627	2010
Imaging response criteria for recurrent gliomas treated with bevacizumab: role of diffusion weighted imaging as an imaging biomarker. Journal of neuro-oncology\| PubMed ID: 19859666	2010
Gliosarcoma stem cells undergo glial and mesenchymal differentiation in vivo. Stem cells (Dayton, Ohio)\| PubMed ID: 19937755	2010
The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. Journal of neuro-oncology\| PubMed ID: 19957013	2010
The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19957014	2010
The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19957015	2010
The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19957016	2010
The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19960227	2010
The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19960229	2010
The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19960230	2010
The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. Journal of neuro-oncology\| PubMed ID: 19960231	2010
Rebound tumour progression after the cessation of bevacizumab therapy in patients with recurrent high-grade glioma. Journal of neuro-oncology\| PubMed ID: 20151176	2010
Treatment induced necrosis versus recurrent/progressing brain tumor: going beyond the boundaries of conventional morphologic imaging. Journal of neuro-oncology\| PubMed ID: 20179990	2010
Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma. Journal of neuro-oncology\| PubMed ID: 20213332	2010
Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20231676	2010
Phase I/II dose escalation trial of concurrent temozolomide and whole brain radiation therapy for multiple brain metastasis. Journal of neuro-oncology\| PubMed ID: 20431907	2010
A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas. Journal of neuro-oncology\| PubMed ID: 20449631	2010
An integrative approach for in silico glioma research. IEEE transactions on bio-medical engineering\| PubMed ID: 20656651	2010
Tumor vascular leakiness and blood volume estimates in oligodendrogliomas using perfusion CT: an analysis of perfusion parameters helping further characterize genetic subtypes as well as dif... Journal of neuro-oncology\| PubMed ID: 20680399	2011
Targeting integrins in malignant glioma. Targeted oncology\| PubMed ID: 20820929	2010
Predicting survival in glioblastomas using diffusion tensor imaging metrics. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 20882608	2010
Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab. Neuro-oncology\| PubMed ID: 21084434	2011
Corticosteroid use in patients with glioblastoma at first or second relapse treated with bevacizumab in the BRAIN study. The oncologist\| PubMed ID: 21147867	2010
Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions. Cellular signalling\| PubMed ID: 21440622	2011
Recurrent high-grade glioma: a diagnostic and therapeutic challenge. Expert review of neurotherapeutics\| PubMed ID: 21469924	2011
Phase I and pharmacokinetic study of COL-3 in patients with recurrent high-grade gliomas. Journal of neuro-oncology\| PubMed ID: 21547395	2011
Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab. Neuro-oncology\| PubMed ID: 21558074	2011
Correlation of immunohistologic and perfusion vascular parameters with MR contrast enhancement using image-guided biopsy specimens in gliomas. Academic radiology\| PubMed ID: 21718954	2011
Cilengitide induces autophagy-mediated cell death in glioma cells. Neuro-oncology\| PubMed ID: 21788343	2011
Differentiating treatment-induced necrosis from recurrent/progressive brain tumor using nonmodel-based semiquantitative indices derived from dynamic contrast-enhanced T1-weighted MR perfusio... Neuro-oncology\| PubMed ID: 21803763	2011
Model selection for DCE-T1 studies in glioblastoma. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 22127934	2012
Prediction of glioblastoma multiform response to bevacizumab treatment using multi-parametric MRI. PloS one\| PubMed ID: 22253835	2012
Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas. Cell cycle (Georgetown, Tex.)\| PubMed ID: 22274399	2012
Integrated morphologic analysis for the identification and characterization of disease subtypes. Journal of the American Medical Informatics Association : JAMIA\| PubMed ID: 22278382	2012
A prognostic gene expression signature in infratentorial ependymoma. Acta neuropathologica\| PubMed ID: 22322993	2012
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22323597	2012
Phase I study of terameprocol in patients with recurrent high-grade glioma. Neuro-oncology\| PubMed ID: 22323663	2012
Development of a novel animal model to differentiate radiation necrosis from tumor recurrence. Journal of neuro-oncology\| PubMed ID: 22407176	2012
Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study. Journal of neuro-oncology\| PubMed ID: 22426926	2012
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma. PloS one\| PubMed ID: 22536446	2012
Segmentation of corpus callosum using diffusion tensor imaging: validation in patients with glioblastoma. BMC medical imaging\| PubMed ID: 22591335	2012
Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma. Science (New York, N.Y.)\| PubMed ID: 22837387	2012
A nano-sized PARACEST-fluorescence imaging contrast agent facilitates and validates in vivo CEST MRI detection of glioma. Nanomedicine (London, England)\| PubMed ID: 22891866	2012
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer cell\| PubMed ID: 23079654	2012
Genomic mapping and survival prediction in glioblastoma: molecular subclassification strengthened by hemodynamic imaging biomarkers. Radiology\| PubMed ID: 23238158	2013
NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Neuro-oncology\| PubMed ID: 23328813	2013
Phase I study of GRN1005 in recurrent malignant glioma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23349317	2013
A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23363814	2013
MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor. PloS one\| PubMed ID: 23390502	2013
MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set. Radiology\| PubMed ID: 23392431	2013
Morphologic MRI features, diffusion tensor imaging and radiation dosimetric analysis to differentiate pseudo-progression from early tumor progression. Journal of neuro-oncology\| PubMed ID: 23417357	2013
Histological predictors of outcome in ependymoma are dependent on anatomic site within the central nervous system. Brain pathology (Zurich, Switzerland)\| PubMed ID: 23452038	2013
Prognostic vascular imaging biomarkers in high-grade gliomas: tumor permeability as an adjunct to blood volume estimates. Academic radiology\| PubMed ID: 23498990	2013
The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI). Journal of clinical and diagnostic research : JCDR\| PubMed ID: 23543618	2013
Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal. Oncotarget\| PubMed ID: 23548312	2013
MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1. Oncotarget\| PubMed ID: 23714687	2013
Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23864165	2013
The integrated landscape of driver genomic alterations in glioblastoma. Nature genetics\| PubMed ID: 23917401	2013
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 23940216	2013
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. Cancer research\| PubMed ID: 23940299	2013
Subcurative radiation significantly increases proliferation, invasion, and migration of primary GBM in vivo. Chinese journal of cancer\| PubMed ID: 24016393	2013
The somatic genomic landscape of glioblastoma. Cell\| PubMed ID: 24120142	2013
Patterns of failure after radiosurgery to two different target volumes of enhancing lesions with and without FLAIR abnormalities in recurrent glioblastoma multiforme. Journal of neuro-oncology\| PubMed ID: 24173682	2013
Machine-based morphologic analysis of glioblastoma using whole-slide pathology images uncovers clinically relevant molecular correlates. PloS one\| PubMed ID: 24236209	2013
Glioblastoma cell enrichment is critical for analysis of phosphorylated drug targets and proteomic-genomic correlations. Cancer research\| PubMed ID: 24346432	2013
Cilengitide-induced temporal variations in transvascular transfer parameters of tumor vasculature in a rat glioma model: identifying potential MRI biomarkers of acute effects. PloS one\| PubMed ID: 24376814	2013