Jordan S. Orange

Center for Human Immunobiology, Texas Children's Hospital and Baylor College of Medicine

Affiliated withTexas Children's Hospital and Baylor College of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2014

Other Publications

Article	Year
Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. The Journal of clinical investigation\| PubMed ID: 12045264	2002
Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12177428	2002
Viral evasion of natural killer cells. Nature immunology\| PubMed ID: 12407408	2002
Human natural killer cell deficiencies and susceptibility to infection. Microbes and infection / Institut Pasteur\| PubMed ID: 12505527	2002
Acute chylothorax in children: selective retention of memory T cells and natural killer cells. The Journal of pediatrics\| PubMed ID: 12970641	2003
Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. The Journal of infectious diseases\| PubMed ID: 14513412	2003
Finding NEMO: genetic disorders of NF-[kappa]B activation. The Journal of clinical investigation\| PubMed ID: 14523034	2003
Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. The Journal of experimental medicine\| PubMed ID: 14568979	2003
The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14612578	2003
Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology\| PubMed ID: 14641613	2003
A patient with severe black fly (Simuliidae) hypersensitivity referred for evaluation of suspected immunodeficiency. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 14989400	2004
The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. The Journal of allergy and clinical immunology\| PubMed ID: 15100680	2004
Natural killer cells inhibit hepatitis C virus expression. Journal of leukocyte biology\| PubMed ID: 15339939	2004
Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. The Journal of allergy and clinical immunology\| PubMed ID: 15356572	2004
Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. Journal of the American Academy of Dermatology\| PubMed ID: 15523349	2004
Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. The Journal of clinical investigation\| PubMed ID: 15578091	2004
Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunological reviews\| PubMed ID: 15661019	2005
Congenital immunodeficiencies and sepsis. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies\| PubMed ID: 15857568	2005
Practice parameter for the diagnosis and management of primary immunodeficiency. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 15945566	2005
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature immunology\| PubMed ID: 16273099	2005
Natural killer cells in human health and disease. Clinical immunology (Orlando, Fla.)\| PubMed ID: 16337194	2006
Development of a clinical assay to evaluate toll-like receptor function. Clinical and vaccine immunology : CVI\| PubMed ID: 16426002	2006
Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology. The Journal of allergy and clinical immunology\| PubMed ID: 16580469	2006
Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. The Journal of cell biology\| PubMed ID: 16606694	2006
Human natural killer cell deficiencies. Current opinion in allergy and clinical immunology\| PubMed ID: 17088643	2006
Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. Clinical immunology (Orlando, Fla.)\| PubMed ID: 17157070	2007
Impaired specific antibody response and increased B-cell population in transient hypogammaglobulinemia of infancy. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 17165264	2006
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. The Journal of biological chemistry\| PubMed ID: 17244613	2007
Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.)\| PubMed ID: 17332376	2007
Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal proasthmatic changes in airway function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17339460	2007
Hypogammaglobulinemia in a pediatric tertiary care setting. Clinical immunology (Orlando, Fla.)\| PubMed ID: 17631052	2007
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature\| PubMed ID: 17632545	2007
The lytic NK cell immunological synapse and sequential steps in its formation. Advances in experimental medicine and biology\| PubMed ID: 17713009	2007
Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. The Journal of experimental medicine\| PubMed ID: 17785506	2007
Myosin IIA is required for cytolytic granule exocytosis in human NK cells. The Journal of experimental medicine\| PubMed ID: 17875677	2007
NKp30 ligation induces rapid activation of the canonical NF-kappaB pathway in NK cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18025182	2007
IKBKG (nuclear factor-kappa B essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function. The Journal of allergy and clinical immunology\| PubMed ID: 18179816	2008
1. Lymphocytes. The Journal of allergy and clinical immunology\| PubMed ID: 18241683	2008
Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18292573	2008
Immunodeficiency disorders. Preface. Immunology and allergy clinics of North America\| PubMed ID: 18424330	2008
Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 18450128	2008
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nature biotechnology\| PubMed ID: 18587387	2008
Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. The Journal of allergy and clinical immunology\| PubMed ID: 18851874	2008
Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 18851875	2008
Formation and function of the lytic NK-cell immunological synapse. Nature reviews. Immunology\| PubMed ID: 19172692	2008
Immune dysregulation in severe influenza. Journal of leukocyte biology\| PubMed ID: 19276177	2009
Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19380804	2009
Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors. The Journal of clinical investigation\| PubMed ID: 19436115	2009
Use of cytokine therapy in primary immunodeficiency. Clinical reviews in allergy & immunology\| PubMed ID: 19449141	2010
Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19454694	2009
Comèl-Netherton syndrome defined as primary immunodeficiency. The Journal of allergy and clinical immunology\| PubMed ID: 19683336	2009
Chipping away at gamma-H2AX foci. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19770593	2009
Use of intravenous immunoglobulin and adjunctive therapies in the treatment of primary immunodeficiencies: A working group report of and study by the Primary Immunodeficiency Committee of th... Clinical immunology (Orlando, Fla.)\| PubMed ID: 19914873	2010
Variants of DENND1B associated with asthma in children. The New England journal of medicine\| PubMed ID: 20032318	2010
Analysis of the NK cell immunological synapse. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 20033638	2010
Quantitative measurement of F-actin accumulation at the NK cell immunological synapse. Journal of immunological methods\| PubMed ID: 20171970	2010
Navigating barriers: the challenge of directed secretion at the natural killer cell lytic immunological synapse. Journal of clinical immunology\| PubMed ID: 20191315	2010
Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology\| PubMed ID: 20337966	2010
Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment. Molecular biology of the cell\| PubMed ID: 20444980	2010
Efficacy and safety of a new 20% immunoglobulin preparation for subcutaneous administration, IgPro20, in patients with primary immunodeficiency. Journal of clinical immunology\| PubMed ID: 20454851	2010
Latent herpesviruses: aligning human and murine NK cells. Blood\| PubMed ID: 20522715	2010
A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA su... Journal of clinical immunology\| PubMed ID: 20652730	2010
A custom 148 gene-based resequencing chip and the SNP explorer software: new tools to study antibody deficiency. Human mutation\| PubMed ID: 20652909	2010
Impact of trough IgG on pneumonia incidence in primary immunodeficiency: A meta-analysis of clinical studies. Clinical immunology (Orlando, Fla.)\| PubMed ID: 20675197	2010
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes & development\| PubMed ID: 20679398	2010
Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20693425	2010
Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor. Journal of leukocyte biology\| PubMed ID: 20940324	2011
Therapeutic use of immunoglobulins. Advances in pediatrics\| PubMed ID: 21056739	2010
Complications of tumor necrosis factor-α blockade in chronic granulomatous disease-related colitis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 21058909	2010
Stem-cell gene therapy for the Wiskott-Aldrich syndrome. The New England journal of medicine\| PubMed ID: 21067383	2010
The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes a... The American journal of pathology\| PubMed ID: 21356351	2011
IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. The Journal of clinical investigation\| PubMed ID: 21383498	2011
Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin. The Journal of allergy and clinical immunology\| PubMed ID: 21458849	2011
Genome-wide association identifies diverse causes of common variable immunodeficiency. The Journal of allergy and clinical immunology\| PubMed ID: 21497890	2011
Eosinophilic fasciitis mimicking angioedema and treatment response to infliximab in a pediatric patient. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 21530881	2011
Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome. Blood\| PubMed ID: 21670465	2011
Congenital alterations of NEMO glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum IgG levels. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology\| PubMed ID: 21704885	2011
Novel inborn error of folate metabolism: identification by exome capture and sequencing of mutations in the MTHFD1 gene in a single proband. Journal of medical genetics\| PubMed ID: 21813566	2011
Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse. PLoS biology\| PubMed ID: 21931536	2011
Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation. Immunologic research\| PubMed ID: 21935653	2011
Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dec... The Journal of allergy and clinical immunology\| PubMed ID: 21962774	2012
Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity. Blood\| PubMed ID: 22123909	2011
Multiple distinct NK-cell synapses. Blood\| PubMed ID: 22174302	2011
CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia. The Journal of allergy and clinical immunology\| PubMed ID: 22197273	2012
Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity. The Journal of allergy and clinical immunology\| PubMed ID: 22336081	2012
Unraveling human natural killer cell deficiency. The Journal of clinical investigation\| PubMed ID: 22354165	2012
Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency. Blood\| PubMed ID: 22427204	2012
Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands. Immunology letters\| PubMed ID: 22445355	2012
Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature medicine\| PubMed ID: 22447074	2012
Presentation of hemophagocytic lymphohistiocytosis due to a novel MUNC 13-4 mutation masked by partial therapeutic immunosuppression. Pediatric rheumatology online journal\| PubMed ID: 22554126	2012
Hypohidrotic ectodermal dysplasia and immunodeficiency with coincident NEMO and EDA mutations. Frontiers in immunology\| PubMed ID: 22566850	2011
Dual channel STED nanoscopy of lytic granules on actin filaments in natural killer cells. Communicative & integrative biology\| PubMed ID: 22808328	2012
Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy,... The Journal of allergy and clinical immunology\| PubMed ID: 22935624	2012
Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity. The Journal of clinical investigation\| PubMed ID: 23006327	2012
NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23066148	2012
CD2 promotes human natural killer cell membrane nanotube formation. PloS one\| PubMed ID: 23112830	2012
Reply: To PMID 22935624. The Journal of allergy and clinical immunology\| PubMed ID: 23273954	2013
Severe combined immunodeficiency resulting from mutations in MTHFD1. Pediatrics\| PubMed ID: 23296427	2013
New views of the human NK cell immunological synapse: recent advances enabled by super- and high-resolution imaging techniques. Frontiers in immunology\| PubMed ID: 23316204	2012
Immunodeficiency in patients with 49,XXXXY chromosomal variation. American journal of medical genetics. Part C, Seminars in medical genetics\| PubMed ID: 23345259	2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset. Blood\| PubMed ID: 23365458	2013
Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 23380217	2013
Rapid activation receptor- or IL-2-induced lytic granule convergence in human natural killer cells requires Src, but not downstream signaling. Blood\| PubMed ID: 23380740	2013
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood\| PubMed ID: 23407547	2013
The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood\| PubMed ID: 23430111	2013
Differential localization of T-bet and Eomes in CD8 T cell memory populations. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23455505	2013
Bioavailability of IgG administered by the subcutaneous route. Journal of clinical immunology\| PubMed ID: 23456255	2013
Pro-asthmatic cytokines regulate unliganded and ligand-dependent glucocorticoid receptor signaling in airway smooth muscle. PloS one\| PubMed ID: 23593222	2013
Prioritization of evidence-based indications for intravenous immunoglobulin. Journal of clinical immunology\| PubMed ID: 23764872	2013
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science (New York, N.Y.)\| PubMed ID: 23845947	2013
Natural killer cell deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 23993353	2013
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Molecular biology of the cell\| PubMed ID: 24088571	2013
GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity. Blood\| PubMed ID: 24227816	2014
Burden of Copy Number Variation in Common Variable Immunodeficiency. Clinical and experimental immunology\| PubMed ID: 24329717	2013
Modeling primary immunodeficiency disease epidemiology and its treatment to estimate latent therapeutic demand for immunoglobulin. Journal of clinical immunology\| PubMed ID: 24338563	2014
Cell biological steps and checkpoints in accessing NK cell cytotoxicity. Immunology and cell biology\| PubMed ID: 24445602	2014
Noncanonical NF-κB Signaling Is Limited by Classical NF-κB Activity. Science signaling\| PubMed ID: 24497610	2014
iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo. Cancer immunology research\| PubMed ID: 24563871	2014
Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts. The Journal of allergy and clinical immunology\| PubMed ID: 24582311	2014