Martin McMahon

Diller Cancer Research Building, University of California, San Francisco

Affiliated withUniversity of California, San Francisco

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 30	2014

Other Publications

Article	Year
Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Experimental cell research\| PubMed ID: 11795943	2002
De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. Journal of virology\| PubMed ID: 11836422	2002
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene\| PubMed ID: 12717425	2003
Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer research\| PubMed ID: 12727824	2003
Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. Experimental cell research\| PubMed ID: 12837288	2003
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature\| PubMed ID: 14520413	2003
DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Molecular and cellular biology\| PubMed ID: 14645540	2003
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. The Journal of clinical investigation\| PubMed ID: 14966563	2004
Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. The Journal of biological chemistry\| PubMed ID: 15128735	2004
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene\| PubMed ID: 15361836	2004
Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Molecular and cellular biology\| PubMed ID: 15572689	2004
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Molecular and cellular biology\| PubMed ID: 15601844	2005
Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. Cell cycle (Georgetown, Tex.)\| PubMed ID: 15917660	2005
Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. Genes, chromosomes & cancer\| PubMed ID: 15929091	2005
Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer research\| PubMed ID: 15930308	2005
The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? Expert opinion on therapeutic targets\| PubMed ID: 16185155	2005
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer research\| PubMed ID: 16266983	2005
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16484370	2006
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes & development\| PubMed ID: 17299132	2007
A model of intussusceptive angiogenesis. Novartis Foundation symposium\| PubMed ID: 18300412	2007
Meeting report: fourth international congress of the Society for Melanoma Research. Pigment cell & melanoma research\| PubMed ID: 18353140	2008
Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment cell & melanoma research\| PubMed ID: 18715233	2008
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nature genetics\| PubMed ID: 19282848	2009
Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008. Pigment cell & melanoma research\| PubMed ID: 19659612	2009
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cellular signalling\| PubMed ID: 19686845	2009
Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. American journal of medical genetics. Part A\| PubMed ID: 20014119	2010
Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer research\| PubMed ID: 20048081	2010
Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Science translational medicine\| PubMed ID: 20371474	2010
RAF translocations expand cancer targets. Nature medicine\| PubMed ID: 20613748	2010
Parsing out the complexity of RAF inhibitor resistance. Pigment cell & melanoma research\| PubMed ID: 21392366	2011
Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. American journal of medical genetics. Part C, Seminars in medical genetics\| PubMed ID: 21495172	2011
Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse. Cancer research\| PubMed ID: 21512141	2011
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science (New York, N.Y.)\| PubMed ID: 21764747	2011
β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer cell\| PubMed ID: 22172720	2011
MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer research\| PubMed ID: 22511580	2012
E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Developmental biology\| PubMed ID: 22537490	2012
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes & development\| PubMed ID: 22549727	2012
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22586120	2012
A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer discovery\| PubMed ID: 22628411	2012
Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (Cambridge, England)\| PubMed ID: 22675209	2012
Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. Molecular cancer research : MCR\| PubMed ID: 22833572	2012
B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer research\| PubMed ID: 22836754	2012
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes & development\| PubMed ID: 22892241	2012
Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. The Journal of pathology\| PubMed ID: 22951975	2013
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature\| PubMed ID: 23123854	2012
Elucidating distinct roles for NF1 in melanomagenesis. Cancer discovery\| PubMed ID: 23171796	2013
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature\| PubMed ID: 23302800	2013
Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer discovery\| PubMed ID: 23965987	2013
Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer research\| PubMed ID: 24019382	2013
Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Human molecular genetics\| PubMed ID: 24057668	2014
Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24145418	2013
Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Molecular cancer research : MCR\| PubMed ID: 24152792	2013
Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. The Journal of clinical investigation\| PubMed ID: 24200692	2013
BRAFV600E Cooperates with PI3'-Kinase Signaling, Independent of AKT, to Regulate Melanoma Cell Proliferation. Molecular cancer research : MCR\| PubMed ID: 24425783	2014