Sven Hammerschmidt

Department Genetics of Microorganisms, University of Greifswald

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2014

Other Publications

Article	Year
Molecular cloning of an alpha-enolase from the human filarial parasite Onchocerca volvulus that binds human plasminogen. Biochimica et biophysica acta\| PubMed ID: 12818429	2003
Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae. Molecular microbiology\| PubMed ID: 12828639	2003
Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. The Journal of biological chemistry\| PubMed ID: 14660617	2004
Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein. Infection and immunity\| PubMed ID: 15039372	2004
Binding of alpha2-macroglobulin to GRAB (Protein G-related alpha2-macroglobulin-binding protein), an important virulence factor of group A streptococci, is mediated by two charged motifs in ... The Biochemical journal\| PubMed ID: 15113281	2004
Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15210807	2004
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. The Journal of biological chemistry\| PubMed ID: 15215247	2004
Characterization of plasmin(ogen) binding to Streptococcus pneumoniae. The Indian journal of medical research\| PubMed ID: 15232158	2004
Characterization of the interaction of the pneumococcal surface protein SpsA with the human polymeric immunoglobulin receptor (hpIgR). The Indian journal of medical research\| PubMed ID: 15232164	2004
Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infection and immunity\| PubMed ID: 15321985	2004
The cell wall subproteome of Listeria monocytogenes. Proteomics\| PubMed ID: 15378750	2004
Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites. Journal of molecular biology\| PubMed ID: 15476816	2004
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. The Journal of biological chemistry\| PubMed ID: 15485852	2004
PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infection and immunity\| PubMed ID: 15845469	2005
Cloning, characterization and DNA immunization of an Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH). Biochimica et biophysica acta\| PubMed ID: 15955451	2005
Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infection and immunity\| PubMed ID: 16040978	2005
Threat of infection: microbes of high pathogenic potential--strategies for detection, control and eradication. International journal of medical microbiology : IJMM\| PubMed ID: 16044855	2005
Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thrombosis and haemostasis\| PubMed ID: 16113818	2005
The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration... Thrombosis and haemostasis\| PubMed ID: 16113819	2005
The streptococcal lipoprotein rotamase A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonization. The Journal of biological chemistry\| PubMed ID: 16260779	2006
Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16299055	2006
Adherence molecules of pathogenic pneumococci. Current opinion in microbiology\| PubMed ID: 16338163	2006
Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition. The Journal of biological chemistry\| PubMed ID: 16423833	2006
Versatility of pneumococcal surface proteins. Microbiology (Reading, England)\| PubMed ID: 16436417	2006
Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology (Reading, England)\| PubMed ID: 16622048	2006
Regulation of production of mucosal antibody to pneumococcal protein antigens by T-cell-derived gamma interferon and interleukin-10 in children. Infection and immunity\| PubMed ID: 16861661	2006
Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis. Journal of bacteriology\| PubMed ID: 17307854	2007
The host immune regulator factor H interacts via two contact sites with the PspC protein of Streptococcus pneumoniae and mediates adhesion to host epithelial cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17442969	2007
Thrombospondin-1 promotes cellular adherence of gram-positive pathogens via recognition of peptidoglycan. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17507668	2007
Binding of human plasminogen to Bifidobacterium. Journal of bacteriology\| PubMed ID: 17557824	2007
Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. Cytokine\| PubMed ID: 17611121	2007
Fibrinolysis and host response in bacterial infections. Thrombosis and haemostasis\| PubMed ID: 17849039	2007
The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci. FEMS immunology and medical microbiology\| PubMed ID: 18462389	2008
Plasminogen-dependent proteolytic activity in Bifidobacterium lactis. Microbiology (Reading, England)\| PubMed ID: 18667578	2008
Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells. Infection and immunity\| PubMed ID: 18981243	2009
Surface-exposed adherence molecules of Streptococcus pneumoniae. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19089373	2009
Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells. Journal of cell science\| PubMed ID: 19118218	2009
Defining the structural basis of human plasminogen binding by streptococcal surface enolase. The Journal of biological chemistry\| PubMed ID: 19363026	2009
The complement fitness factor H: role in human diseases and for immune escape of pathogens, like pneumococci. Vaccine\| PubMed ID: 19388168	2008
Cdc42 and the phosphatidylinositol 3-kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells. The Journal of biological chemistry\| PubMed ID: 19473971	2009
Pneumococcal interaction with human dendritic cells: phagocytosis, survival, and induced adaptive immune response are manipulated by PavA. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19570831	2009
Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology (Reading, England)\| PubMed ID: 19574304	2009
Fibronectin stimulates Escherichia coli phagocytosis by microglial cells. Glia\| PubMed ID: 19780198	2010
Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1. Thrombosis and haemostasis\| PubMed ID: 19806260	2009
Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infection and immunity\| PubMed ID: 19933834	2010
DnaK from Bifidobacterium animalis subsp. lactis is a surface-exposed human plasminogen receptor upregulated in response to bile salts. Microbiology (Reading, England)\| PubMed ID: 20167618	2010
PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections. Molecular microbiology\| PubMed ID: 20444103	2010
Complement regulator Factor H mediates a two-step uptake of Streptococcus pneumoniae by human cells. The Journal of biological chemistry\| PubMed ID: 20504767	2010
TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20525885	2010
Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-te... The Journal of biological chemistry\| PubMed ID: 20829350	2010
Platelet factor 4 binds to bacteria, [corrected] inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood\| PubMed ID: 20959601	2011
Impact of glutamine transporters on pneumococcal fitness under infection-related conditions. Infection and immunity\| PubMed ID: 21078855	2011
Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic Streptococci and Enterococci. International journal of medical microbiology : IJMM\| PubMed ID: 21112248	2011
Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo. Immunity\| PubMed ID: 21349432	2011
Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores. The Journal of biological chemistry\| PubMed ID: 21454571	2011
Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease. Blood\| PubMed ID: 21659541	2011
Relevance of Bifidobacterium animalis subsp. lactis plasminogen binding activity in the human gastrointestinal microenvironment. Applied and environmental microbiology\| PubMed ID: 21821753	2011
Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. Cellular microbiology\| PubMed ID: 21999205	2012
The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22003197	2011
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22156592	2012
Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. The Journal of biological chemistry\| PubMed ID: 22167202	2012
Combat pneumococcal infections: adhesins as candidates for protein-based vaccine development. Current drug targets\| PubMed ID: 22206255	2012
Heterologous expression of pneumococcal virulence factor PspC on the surface of Lactococcus lactis confers adhesive properties. Microbiology (Reading, England)\| PubMed ID: 22222496	2012
Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. Applied and environmental microbiology\| PubMed ID: 22287006	2012
TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia. The European respiratory journal\| PubMed ID: 22653776	2013
Enolase of Streptococcus pneumoniae binds human complement inhibitor C4b-binding protein and contributes to complement evasion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22925928	2012
Platelet factor 4 binding to lipid A of Gram-negative bacteria exposes PF4/heparin-like epitopes. Blood\| PubMed ID: 22942185	2012
High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis. Brain : a journal of neurology\| PubMed ID: 23518713	2013
The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin. The Journal of biological chemistry\| PubMed ID: 23603906	2013
Structural reevaluation of Streptococcus pneumoniae Lipoteichoic acid and new insights into its immunostimulatory potency. The Journal of biological chemistry\| PubMed ID: 23603911	2013
Lung dendritic cells facilitate extrapulmonary bacterial dissemination during pneumococcal pneumonia. Frontiers in cellular and infection microbiology\| PubMed ID: 23802100	2013
The interaction between bacterial enolase and plasminogen promotes adherence of Streptococcus pneumoniae to epithelial and endothelial cells. International journal of medical microbiology : IJMM\| PubMed ID: 23906818	2013
Exploitation of physiology and metabolomics to identify pneumococcal vaccine candidates. Expert review of vaccines\| PubMed ID: 24053399	2013
Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence. EMBO molecular medicine\| PubMed ID: 24136784	2013
Repeating structures of the major staphylococcal autolysin are essential for the interaction with human thrombospondin 1 and vitronectin. The Journal of biological chemistry\| PubMed ID: 24371140	2014
Influence of Impaired Lipoprotein Biogenesis on Surface and Exoproteome of Streptococcus pneumoniae. Journal of proteome research\| PubMed ID: 24387739	2014