Val J. Watts

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University

Research Area

Biography

Val J. Watts has not added Biography.
If you are Val J. Watts and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2014

Other Publications

Article	Year
Molecular mechanisms for heterologous sensitization of adenylate cyclase. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12065693	2002
Heterologous sensitization of adenylate cyclase is protein kinase A-dependent in Cath.a differentiated (CAD)-D2L cells. Journal of neurochemistry\| PubMed ID: 12358756	2002
Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12490596	2003
A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. Journal of neurochemistry\| PubMed ID: 12887695	2003
Sensitization of adenylate cyclase: a general mechanism of neuroadaptation to persistent activation of Galpha(i/o)-coupled receptors? Life sciences\| PubMed ID: 14519441	2003
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14566008	2004
Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors. Cellular signalling\| PubMed ID: 14575866	2003
Novel regulatory properties of human type 9 adenylate cyclase. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 14996950	2004
Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line. Journal of neurochemistry\| PubMed ID: 15009651	2004
Sexual experience alters D1 receptor-mediated cyclic AMP production in the nucleus accumbens of female Syrian hamsters. Synapse (New York, N.Y.)\| PubMed ID: 15150737	2004
Using molecular tools to dissect the role of Galphas in sensitization of AC1. Molecular pharmacology\| PubMed ID: 15361543	2004
Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells. Molecular pharmacology\| PubMed ID: 15470083	2005
Activation of a novel PKC isoform synergistically enhances D2L dopamine receptor-mediated sensitization of adenylate cyclase type 6. Cellular signalling\| PubMed ID: 15683739	2005
Galphaq potentiation of adenylate cyclase type 9 activity through a Ca2+/calmodulin-dependent pathway. Biochemical pharmacology\| PubMed ID: 15794946	2005
Galphaq-coupled receptor signaling enhances adenylate cyclase type 6 activation. Biochemical pharmacology\| PubMed ID: 15885660	2005
Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1. Biochemical and biophysical research communications\| PubMed ID: 15913563	2005
Sensitization of adenylate cyclase by Galpha i/o-coupled receptors. Pharmacology & therapeutics\| PubMed ID: 15922020	2005
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange. Structure (London, England : 1993)\| PubMed ID: 16004878	2005
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity. FEBS letters\| PubMed ID: 16225870	2005
D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent. Neuropharmacology\| PubMed ID: 16376953	2006
Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. Molecular pharmacology\| PubMed ID: 16489124	2006
Regulatory properties of adenylate cyclases type 5 and 6: A progress report. European journal of pharmacology\| PubMed ID: 16527269	2006
Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters. Psychopharmacology\| PubMed ID: 16850118	2006
WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology\| PubMed ID: 16915381	2006
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of medicinal chemistry\| PubMed ID: 17154515	2006
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection. Molecular interventions\| PubMed ID: 17468386	2007
Adenylyl cyclase 5: a new clue in the search for the "fountain of youth"? Science's STKE : signal transduction knowledge environment\| PubMed ID: 18029912	2007
Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Molecular pharmacology\| PubMed ID: 18524886	2008
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics. The Journal of biological chemistry\| PubMed ID: 18984596	2008
Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane. FEBS letters\| PubMed ID: 19013155	2008
Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology\| PubMed ID: 19028082	2009
Fluorescent and bioluminescent protein-fragment complementation assays in the study of G protein-coupled receptor oligomerization and signaling. Molecular pharmacology\| PubMed ID: 19141658	2009
The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 19351867	2009
Ligand-induced regulation and localization of cannabinoid CB1 and dopamine D2L receptor heterodimers. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 20016021	2010
Visualization of G protein-coupled receptor (GPCR) interactions in living cells using bimolecular fluorescence complementation (BiFC). Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 20373507	2010
Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling. Molecular and cellular endocrinology\| PubMed ID: 20654687	2011
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorganic & medicinal chemistry\| PubMed ID: 20709559	2010
Molecular and pharmacological characterization of two D(1)-like dopamine receptors in the Lyme disease vector, Ixodes scapularis. Insect biochemistry and molecular biology\| PubMed ID: 21457782	2011
Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. ChemMedChem\| PubMed ID: 21538900	2011
Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of medicinal chemistry\| PubMed ID: 21714510	2011
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorganic & medicinal chemistry\| PubMed ID: 21862338	2011
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European journal of medicinal chemistry\| PubMed ID: 22204903	2012
Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease. Psychopharmacology\| PubMed ID: 22222862	2012
A "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptors. PLoS neglected tropical diseases\| PubMed ID: 22292096	2012
Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. Molecular pharmacology\| PubMed ID: 22334593	2012
Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly. Journal of signal transduction\| PubMed ID: 22523680	2012
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. Bioorganic & medicinal chemistry\| PubMed ID: 23018094	2012
Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses. Insect biochemistry and molecular biology\| PubMed ID: 23213654	2012
Bimolecular fluorescence complementation analysis of G protein-coupled receptor dimerization in living cells. Methods in enzymology\| PubMed ID: 23351744	2013
Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling. Cellular and molecular neurobiology\| PubMed ID: 23504261	2013
Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience. Brain structure & function\| PubMed ID: 23934655	2013
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 24008337	2013