Leonard K. Kaczmarek

Department of Pharmacology, Yale School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2014

Other Publications

Article	Year
Protein kinase modulation of a neuronal cation channel requires protein-protein interactions mediated by an Src homology 3 domain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11756482	2002
Endogenous parathyroid hormone-related protein functions as a neuroprotective agent. Brain research\| PubMed ID: 11879796	2002
HSV-1 helper virus 5dl1.2 suppresses sodium currents in amplicon-transduced neurons. Journal of neurophysiology\| PubMed ID: 11929932	2002
Localization of the Slack potassium channel in the rat central nervous system. The Journal of comparative neurology\| PubMed ID: 12442315	2002
Prolonged activation of Ca2+-activated K+ current contributes to the long-lasting refractory period of Aplysia bag cell neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12451114	2002
Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12598601	2003
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Developmental cell\| PubMed ID: 12689595	2003
Modulation of mitochondrial function by endogenous Zn2+ pools. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12724524	2003
Compensatory anion currents in Kv1.3 channel-deficient thymocytes. The Journal of biological chemistry\| PubMed ID: 12878608	2003
Modulation of synaptic transmission by the BCL-2 family protein BCL-xL. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12968005	2003
How to make a relationship last: release sites with different levels of commitment. Neuron\| PubMed ID: 14527428	2003
Functional specialization of male and female vocal motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14684859	2003
Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14684870	2003
The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14981264	2004
Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14985434	2004
Act locally: new ways of regulating voltage-gated ion channels. Molecular interventions\| PubMed ID: 14993392	2002
Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal of neurobiology\| PubMed ID: 15307146	2004
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15342906	2004
The appearance of a protein kinase A-regulated splice isoform of slo is associated with the maturation of neurons that control reproductive behavior. The Journal of biological chemistry\| PubMed ID: 15375169	2004
Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies. Journal of neurobiology\| PubMed ID: 15547932	2005
Exposure to hypoxia rapidly induces mitochondrial channel activity within a living synapse. The Journal of biological chemistry\| PubMed ID: 15561723	2005
Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science (New York, N.Y.)\| PubMed ID: 15637280	2005
Localization of the Na+-activated K+ channel Slick in the rat central nervous system. The Journal of comparative neurology\| PubMed ID: 15717307	2005
For K+ channels, Na+ is the new Ca2+. Trends in neurosciences\| PubMed ID: 15979166	2005
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing research\| PubMed ID: 16081004	2005
Actions of BAX on mitochondrial channel activity and on synaptic transmission. Antioxidants & redox signaling\| PubMed ID: 16115013	2005
Association/dissociation of a channel-kinase complex underlies state-dependent modulation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16135761	2005
Acoustic environment determines phosphorylation state of the Kv3.1 potassium channel in auditory neurons. Nature neuroscience\| PubMed ID: 16136041	2005
Retraction. Science (New York, N.Y.)\| PubMed ID: 16373558	2005
Policing the ball: a new potassium channel subunit determines inactivation rate. Neuron\| PubMed ID: 16504937	2006
Modulation of Kv3.1b potassium channel phosphorylation in auditory neurons by conventional and novel protein kinase C isozymes. The Journal of biological chemistry\| PubMed ID: 16595659	2006
Opposite regulation of Slick and Slack K+ channels by neuromodulators. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16687497	2006
Pharmacological activation and inhibition of Slack (Slo2.2) channels. Neuropharmacology\| PubMed ID: 16876206	2006
A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia. Journal of neurophysiology\| PubMed ID: 16885525	2006
Non-conducting functions of voltage-gated ion channels. Nature reviews. Neuroscience\| PubMed ID: 16988652	2006
Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia. Neurogenetics\| PubMed ID: 17136396	2007
Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17344399	2007
Sodium-dependent potassium channels of a Slack-like subtype contribute to the slow afterhyperpolarization in lamprey spinal neurons. The Journal of physiology\| PubMed ID: 17884929	2007
Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical and biophysical research communications\| PubMed ID: 18053804	2008
Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission. Journal of neurophysiology\| PubMed ID: 18160428	2008
Repetitive firing triggers clustering of Kv2.1 potassium channels in Aplysia neurons. The Journal of biological chemistry\| PubMed ID: 18276591	2008
PKC-induced intracellular trafficking of Ca(V)2 precedes its rapid recruitment to the plasma membrane. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18322103	2008
Protein kinase C modulates inactivation of Kv3.3 channels. The Journal of biological chemistry\| PubMed ID: 18539595	2008
Amino-termini isoforms of the Slack K+ channel, regulated by alternative promoters, differentially modulate rhythmic firing and adaptation. The Journal of physiology\| PubMed ID: 18787033	2008
Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19095801	2008
The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19403831	2009
Use of optical biosensors to detect modulation of Slack potassium channels by G protein-coupled receptors. Journal of receptor and signal transduction research\| PubMed ID: 19640220	2009
Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. The Journal of physiology\| PubMed ID: 20308249	2010
The slack sodium-activated potassium channel provides a major outward current in olfactory neurons of Kv1.3-/- super-smeller mice. Journal of neurophysiology\| PubMed ID: 20393063	2010
Controlling auditory excitability: the benefits of a cultured environment. The Journal of physiology\| PubMed ID: 20436041	2010
Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack. Nature neuroscience\| PubMed ID: 20512134	2010
Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons. The Journal of comparative neurology\| PubMed ID: 20575068	2010
A less flexible BK channel opens more easily. Neuron\| PubMed ID: 20620867	2010
Fragile X mental retardation protein is required for rapid experience-dependent regulation of the potassium channel Kv3.1b. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20685971	2010
Potassium channel modulation and auditory processing. Hearing research\| PubMed ID: 21414395	2011
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. The Journal of cell biology\| PubMed ID: 21987637	2011
Gradients and modulation of K(+) channels optimize temporal accuracy in networks of auditory neurons. PLoS computational biology\| PubMed ID: 22438799	2012
De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nature genetics\| PubMed ID: 23086397	2012
Regulation of neuronal excitability by interaction of fragile X mental retardation protein with slack potassium channels. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23115170	2012
An evolutionarily conserved mode of modulation of Shaw-like Kâº channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23233530	2013
A sodium-activated potassium channel supports high-frequency firing and reduces energetic costs during rapid modulations of action potential amplitude. Journal of neurophysiology\| PubMed ID: 23324315	2013
Expression of Kv1.3 potassium channels regulates density of cortical interneurons. Developmental neurobiology\| PubMed ID: 23821603	2013
Slack, Slick and Sodium-Activated Potassium Channels. ISRN neuroscience\| PubMed ID: 24319675	2013
The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Frontiers in cellular neuroscience\| PubMed ID: 24368895	2013
Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. Human molecular genetics\| PubMed ID: 24463883	2014