Celina G. Kleer

Department of Pathology, University of Michigan Comprehensive Cancer Center

Affiliated withUniversity of Michigan Comprehensive Cancer Center

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2014

Other Publications

Article	Year
Characterization of RhoC expression in benign and malignant breast disease: a potential new marker for small breast carcinomas with metastatic ability. The American journal of pathology\| PubMed ID: 11839578	2002
WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene\| PubMed ID: 12082632	2002
Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression. Endocrine pathology\| PubMed ID: 12114819	2000
Detection of Epstein-Barr virus in rapidly growing fibroadenomas of the breast in immunosuppressed hosts. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 12118114	2002
Alpha-Methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. The American journal of surgical pathology\| PubMed ID: 12131161	2002
Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer research\| PubMed ID: 12208730	2002
Lymphocytic mastitis and diabetic mastopathy: a molecular, immunophenotypic, and clinicopathologic evaluation of 11 cases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 12640102	2003
Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells. Cancer cell\| PubMed ID: 12781365	2003
Antiangiogenic tetrathiomolybdate enhances the efficacy of doxorubicin against breast carcinoma. Molecular cancer therapeutics\| PubMed ID: 12883034	2003
Sentinel node biopsy prior to neoadjuvant chemotherapy. American journal of surgery\| PubMed ID: 12885598	2003
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14500907	2003
E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast cancer research : BCR\| PubMed ID: 14580257	2003
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer. Breast cancer research : BCR\| PubMed ID: 14696649	2004
Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines. Cancer research\| PubMed ID: 14729606	2004
WISP3 (CCN6) is a secreted tumor-suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia (New York, N.Y.)\| PubMed ID: 15140407	2004
p63 expression in breast cancer: a highly sensitive and specific marker of metaplastic carcinoma. The American journal of surgical pathology\| PubMed ID: 15489655	2004
Small (< 2.0-cm) breast cancers: mammographic and US findings at US-guided cryoablation--initial experience. Radiology\| PubMed ID: 15567802	2004
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer. Breast cancer research : BCR\| PubMed ID: 15602803	2004
A pilot study to establish a clinical model to perform phase II studies of breast cancer chemopreventive agents in women at high risk with biomarkers as surrogate endpoints for activity. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15623610	2004
Pathologic features of breast cancer associated with complete response to neoadjuvant chemotherapy: importance of tumor necrosis. The American journal of surgical pathology\| PubMed ID: 15725804	2005
Alpha-methylacyl-CoA racemase protein expression is associated with the degree of differentiation in breast cancer using quantitative image analysis. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 15941950	2005
Comprehensive axillary evaluation in neoadjuvant chemotherapy patients with ultrasonography and sentinel lymph node biopsy. Annals of surgical oncology\| PubMed ID: 16079956	2005
Clinical and radiologic assessments to predict breast cancer pathologic complete response to neoadjuvant chemotherapy. Breast cancer research and treatment\| PubMed ID: 16155794	2005
Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer research\| PubMed ID: 16166314	2005
RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast. Breast cancer research and treatment\| PubMed ID: 16187229	2005
Is lobular carcinoma in situ as a component of breast carcinoma a risk factor for local failure after breast-conserving therapy? Results of a matched pair analysis. Cancer\| PubMed ID: 16329136	2006
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells. Neoplasia (New York, N.Y.)\| PubMed ID: 16331887	2005
Identification of GATA3 as a breast cancer prognostic marker by global gene expression meta-analysis. Cancer research\| PubMed ID: 16357129	2005
A putative role for psoriasin in breast tumor progression. Cancer research\| PubMed ID: 16357139	2005
Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 16424892	2006
Inhibition of CCN6 (WISP3) expression promotes neoplastic progression and enhances the effects of insulin-like growth factor-1 on breast epithelial cells. Breast cancer research : BCR\| PubMed ID: 16457688	2005
Identification of EZH2 as a molecular marker for a precancerous state in morphologically normal breast tissues. Cancer research\| PubMed ID: 16618729	2006
ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease. Neoplasia (New York, N.Y.)\| PubMed ID: 16756724	2006
The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer. Journal of molecular histology\| PubMed ID: 16855786	2006
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16899593	2006
Changes in surgical management resulting from case review at a breast cancer multidisciplinary tumor board. Cancer\| PubMed ID: 16998942	2006
Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast. Cancer research\| PubMed ID: 17018586	2006
Significance of flat epithelial atypia on mammotome core needle biopsy: Should it be excised? Human pathology\| PubMed ID: 17095049	2007
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer research\| PubMed ID: 17483331	2007
CCN6 (WISP3) as a new regulator of the epithelial phenotype in breast cancer. Cells, tissues, organs\| PubMed ID: 17587813	2007
Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer research\| PubMed ID: 17596595	2007
Expression of polycomb group protein EZH2 in nevi and melanoma. Journal of cutaneous pathology\| PubMed ID: 17640228	2007
Sentinel lymph node biopsy for breast cancer: how many nodes are enough? Journal of surgical oncology\| PubMed ID: 17685432	2007
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17898181	2007
Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients. Breast cancer research and treatment\| PubMed ID: 18058225	2008
BRCA1 regulates human mammary stem/progenitor cell fate. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18230721	2008
Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. The American journal of pathology\| PubMed ID: 18321996	2008
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell stem cell\| PubMed ID: 18371393	2007
Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18593979	2008
Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18765527	2008
Axillary staging prior to neoadjuvant chemotherapy for breast cancer: predictors of recurrence. Annals of surgical oncology\| PubMed ID: 18784961	2008
Tubular carcinoma and grade 1 (well-differentiated) invasive ductal carcinoma: comparison of flat epithelial atypia and other intra-epithelial lesions. Pathology international\| PubMed ID: 18801081	2008
Residual disease after re-excision lumpectomy for close margins. Journal of surgical oncology\| PubMed ID: 19065638	2009
Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients. Breast (Edinburgh, Scotland)\| PubMed ID: 19157876	2009
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. The American journal of pathology\| PubMed ID: 19411448	2009
Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy. Cell cycle (Georgetown, Tex.)\| PubMed ID: 19448435	2009
AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19487683	2009
Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. The American journal of pathology\| PubMed ID: 19661437	2009
Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions. Archives of pathology & laboratory medicine\| PubMed ID: 19886718	2009
Antiangiogenic tetrathiomolybdate protects against Her2/neu-induced breast carcinoma by hypoplastic remodeling of the mammary gland. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19934283	2009
Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. Cancer research\| PubMed ID: 20395207	2010
Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma. Human pathology\| PubMed ID: 20573371	2010
African ancestry and higher prevalence of triple-negative breast cancer: findings from an international study. Cancer\| PubMed ID: 20629078	2010
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer research\| PubMed ID: 21224357	2011
Membrane localization of insulin receptor substrate-2 (IRS-2) is associated with decreased overall survival in breast cancer. Breast cancer research and treatment\| PubMed ID: 21258861	2011
EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 21399615	2011
Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer. Cancer research\| PubMed ID: 21406404	2011
CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. Journal of cell science\| PubMed ID: 21525039	2011
Increased risk for distant metastasis in patients with familial early-stage breast cancer and high EZH2 expression. Breast cancer research and treatment\| PubMed ID: 21614565	2012
Survival of inflammatory breast cancer patients compared to non-inflammatory breast cancer patients in Egypt. The breast journal\| PubMed ID: 21827567	2011
On how CCN6 suppresses breast cancer growth and invasion. Journal of cell communication and signaling\| PubMed ID: 21842227	2012
p38γ promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior. Cancer research\| PubMed ID: 21862636	2011
Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transition. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 22080057	2012
Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer. Nature medicine\| PubMed ID: 22101766	2011
Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer metastasis reviews\| PubMed ID: 22366781	2012
Invasive breast carcinomas in Ghana: high frequency of high grade, basal-like histology and high EZH2 expression. Breast cancer research and treatment\| PubMed ID: 22527102	2012
CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer. Cancer research\| PubMed ID: 22805309	2012
Metaplastic carcinomas of the breast: diagnostic challenges and new translational insights. Archives of pathology & laboratory medicine\| PubMed ID: 22849737	2012
RhoC impacts the metastatic potential and abundance of breast cancer stem cells. PloS one\| PubMed ID: 22911725	2012
Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women. Cancer\| PubMed ID: 22930220	2013
Inflammatory breast cancer in north Africa: comparison of clinical and molecular epidemiologic characteristics of patients from Egypt, Tunisia, and Morocco. Breast disease\| PubMed ID: 23001584	2011-2012
Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23011797	2012
CCN6 knockdown disrupts acinar organization of breast cells in three-dimensional cultures through up-regulation of type III TGF-β receptor. Neoplasia (New York, N.Y.)\| PubMed ID: 23226100	2012
HER2 drives luminal breast cancer stem cells in the absence of HER2 amplification: implications for efficacy of adjuvant trastuzumab. Cancer research\| PubMed ID: 23442322	2013
Invasive ductal carcinoma with lobular features: a comparison study to invasive ductal and invasive lobular carcinomas of the breast. Breast cancer research and treatment\| PubMed ID: 23535842	2013
EZH2 inhibition decreases p38 signaling and suppresses breast cancer motility and metastasis. Breast cancer research and treatment\| PubMed ID: 23539298	2013
Tissue-based identification of stem cells and epithelial-to-mesenchymal transition in breast cancer. Human pathology\| PubMed ID: 23574782	2013
EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23759596	2013
Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell\| PubMed ID: 23827675	2013
EZH2 expands breast stem cells through activation of NOTCH1 signaling. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24516139	2014