Melody A. Swartz

Institute of Bioengineering and Swiss Institute of Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne

Affiliated withÉcole Polytechnique Fédérale de Lausanne

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 21	2014

Other Publications

Article	Year
Physiological 3D tissue model of the airway wall and mucosa. Nature protocols\| PubMed ID: 17406256	2006
Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 11943653	2002
Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 12531726	2003
The role of interstitial stress in lymphatic function and lymphangiogenesis. Annals of the New York Academy of Sciences\| PubMed ID: 12543729	2002
Interstitial flow as a guide for lymphangiogenesis. Circulation research\| PubMed ID: 12623882	2003
An in vitro airway wall model of remodeling. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12851213	2003
Signaling in morphogenesis: transport cues in morphogenesis. Current opinion in biotechnology\| PubMed ID: 14580587	2003
Interstitial flow differentially stimulates blood and lymphatic endothelial cell morphogenesis in vitro. Microvascular research\| PubMed ID: 15501245	2004
Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. Journal of the National Cancer Institute\| PubMed ID: 15632376	2005
Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin. Circulation research\| PubMed ID: 15890974	2005
Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nature reviews. Immunology\| PubMed ID: 16056255	2005
Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro. Journal of cell science\| PubMed ID: 16188933	2005
Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16249343	2005
Mechanobiology in the third dimension. Annals of biomedical engineering\| PubMed ID: 16341917	2005
Microarray analysis of VEGF-C responsive genes in human lymphatic endothelial cells. Lymphatic research and biology\| PubMed ID: 16379588	2005
Mechanisms of interstitial flow-induced remodeling of fibroblast-collagen cultures. Annals of biomedical engineering\| PubMed ID: 16482410	2006
Capturing complex 3D tissue physiology in vitro. Nature reviews. Molecular cell biology\| PubMed ID: 16496023	2006
In vivo targeting of dendritic cells in lymph nodes with poly(propylene sulfide) nanoparticles. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 16529839	2006
Extracellular matrix remodeling by dynamic strain in a three-dimensional tissue-engineered human airway wall model. American journal of respiratory cell and molecular biology\| PubMed ID: 16601241	2006
Autologous morphogen gradients by subtle interstitial flow and matrix interactions. Biophysical journal\| PubMed ID: 16603487	2006
Characterization of lymphangiogenesis in a model of adult skin regeneration. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 16648194	2006
A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 16763103	2006
Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9. Microvascular research\| PubMed ID: 16876204	2006
Effects of extracellular fiber architecture on cell membrane shear stress in a 3D fibrous matrix. Journal of biomechanics\| PubMed ID: 16987520	2007
Targeting dendritic cells with biomaterials: developing the next generation of vaccines. Trends in immunology\| PubMed ID: 17049307	2006
Engineered blood and lymphatic capillaries in 3-D VEGF-fibrin-collagen matrices with interstitial flow. Biotechnology and bioengineering\| PubMed ID: 17133613	2007
A driving force for change: interstitial flow as a morphoregulator. Trends in cell biology\| PubMed ID: 17141502	2007
Regulation of lymphatic capillary regeneration by interstitial flow in skin. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 17189348	2007
Cooperative and redundant roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 17210781	2007
Bond-detach lithography: a method for micro/nanolithography by precision PDMS patterning. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 17294484	2007
Interstitial flow and its effects in soft tissues. Annual review of biomedical engineering\| PubMed ID: 17459001	2007
An ultra-thin PDMS membrane as a bio/micro-nano interface: fabrication and characterization. Biomedical microdevices\| PubMed ID: 17516172	2007
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer cell\| PubMed ID: 17560334	2007
Exploiting lymphatic transport and complement activation in nanoparticle vaccines. Nature biotechnology\| PubMed ID: 17873867	2007
Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 18024723	2008
Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design. Seminars in immunology\| PubMed ID: 18201895	2008
Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype. Cancer research\| PubMed ID: 19118020	2009
3D collagen cultures under well-defined dynamic strain: a novel strain device with a porous elastomeric support. Biotechnology and bioengineering\| PubMed ID: 19148875	2009
In vitro models of inhalation toxicity and disease. The report of a FRAME workshop. Alternatives to laboratory animals : ATLA\| PubMed ID: 19292579	2009
An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies. Biomedical microdevices\| PubMed ID: 19343497	2009
A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics. Biotechnology and bioengineering\| PubMed ID: 19396808	2009
Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. The American journal of pathology\| PubMed ID: 19679879	2009
Fluid flow regulates stromal cell organization and CCL21 expression in a tissue-engineered lymph node microenvironment. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19734211	2009
Materials engineering for immunomodulation. Nature\| PubMed ID: 19940915	2009
A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: development, characterization, and applications. Biotechnology and bioengineering\| PubMed ID: 19953672	2010
Cells in 3D matrices under interstitial flow: effects of extracellular matrix alignment on cell shear stress and drag forces. Journal of biomechanics\| PubMed ID: 20006339	2010
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. The American journal of pathology\| PubMed ID: 20110415	2010
Transmural flow modulates cell and fluid transport functions of lymphatic endothelium. Circulation research\| PubMed ID: 20133901	2010
Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21. Science (New York, N.Y.)\| PubMed ID: 20339029	2010
Role of lymphatic vessels in tumor immunity: passive conduits or active participants? Journal of mammary gland biology and neoplasia\| PubMed ID: 20835756	2010
Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation. Vaccine\| PubMed ID: 20934457	2010
PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration. Vaccine\| PubMed ID: 21094269	2011
Engineering complement activation on polypropylene sulfide vaccine nanoparticles. Biomaterials\| PubMed ID: 21183216	2011
Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts. Cancer research\| PubMed ID: 21245098	2011
Regulation of tumor invasion by interstitial fluid flow. Physical biology\| PubMed ID: 21301060	2011
Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21422278	2011
Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis. Vaccine\| PubMed ID: 21787826	2011
Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 21864593	2011
PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: tumor immunotoxicity in B16F10 melanoma. Biomaterials\| PubMed ID: 21924769	2011
Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21969597	2011
Multiscale modeling of lymphatic drainage from tissues using homogenization theory. Journal of biomechanics\| PubMed ID: 22036032	2012
Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 22143066	2012
Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity. Nature reviews. Cancer\| PubMed ID: 22362216	2012
Tumor microenvironment complexity: emerging roles in cancer therapy. Cancer research\| PubMed ID: 22414581	2012
Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes. Biomaterials\| PubMed ID: 22658634	2012
Polymer micelles with pyridyl disulfide-coupled antigen travel through lymphatics and show enhanced cellular responses following immunization. Acta biomaterialia\| PubMed ID: 22698945	2012
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. Physiological reviews\| PubMed ID: 22811424	2012
VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics. Cell reports\| PubMed ID: 22832193	2012
Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22844119	2012
Engineering approaches to immunotherapy. Science translational medicine\| PubMed ID: 22914624	2012
Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization. Vaccine\| PubMed ID: 23103199	2012
ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. PloS one\| PubMed ID: 23251384	2012
Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism. Cancer research\| PubMed ID: 23271726	2013
Intravital immunofluorescence for visualizing the microcirculatory and immune microenvironments in the mouse ear dermis. PloS one\| PubMed ID: 23451163	2013
Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles. Biomaterials\| PubMed ID: 23478034	2013
Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice. The Journal of clinical investigation\| PubMed ID: 23524964	2013
Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23530147	2013
Peripherally administered nanoparticles target monocytic myeloid cells, secondary lymphoid organs and tumors in mice. PloS one\| PubMed ID: 23626707	2013
The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165. Biomaterials\| PubMed ID: 23683723	2013
Cooperative roles of SDF-1α and EGF gradients on tumor cell migration revealed by a robust 3D microfluidic model. PloS one\| PubMed ID: 23869217	2013
Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis. Angiogenesis\| PubMed ID: 23892627	2014
VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. The American journal of pathology\| PubMed ID: 24036251	2013
Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response. Biomaterials\| PubMed ID: 24144906	2014
Engineering synthetic vaccines using cues from natural immunity. Nature materials\| PubMed ID: 24150416	2013
Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24248387	2013
Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science (New York, N.Y.)\| PubMed ID: 24558160	2014
Emerging roles of lymphatic endothelium in regulating adaptive immunity. The Journal of clinical investigation\| PubMed ID: 24590280	2014
Introduction to the special issue on lymphangiogenesis in inflammation. Angiogenesis\| PubMed ID: 24671660	2014