Huaxin Sheng

Multidisciplinary Neuroprotection Laboratories, Duke University

Affiliated withDuke University Duke University Medical Center

Research Area

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JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 33	2014
Publication title Cited by 3	2023
Publication title Cited by 6	2023
Publication title	2025

Other Publications

Article	Year
Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 11959653	2002
Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurological research\| PubMed ID: 12117325	2002
Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke; a journal of cerebral circulation\| PubMed ID: 12215605	2002
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free radical biology & medicine\| PubMed ID: 12361805	2002
A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free radical biology & medicine\| PubMed ID: 12374626	2002
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 12468796	2002
Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. Free radical biology & medicine\| PubMed ID: 12488134	2002
Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 12574555	2003
Catalytic Antioxidants as Novel Pharmacologic Approaches to Treatment of Ischemic Brain Injury. Drug news & perspectives\| PubMed ID: 12677251	2002
Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice. Anesthesiology\| PubMed ID: 14576552	2003
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology\| PubMed ID: 15114213	2004
A no-laminectomy spinal cord compression injury model in mice. Journal of neurotrauma\| PubMed ID: 15165367	2004
Mouse spinal cord compression injury is ameliorated by intrathecal cationic manganese(III) porphyrin catalytic antioxidant therapy. Neuroscience letters\| PubMed ID: 15276251	2004
Oxidants, antioxidants and the ischemic brain. The Journal of experimental biology\| PubMed ID: 15299043	2004
Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesthesia and analgesia\| PubMed ID: 15333428	2004
Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. European journal of pharmacology\| PubMed ID: 16455070	2006
A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats. Brain research\| PubMed ID: 16458861	2006
A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocritical care\| PubMed ID: 16498192	2006
Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection. Anesthesiology\| PubMed ID: 16809998	2006
Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. Neurocritical care\| PubMed ID: 16960300	2006
Isoflurane provides long-term protection against focal cerebral ischemia in the rat. Anesthesiology\| PubMed ID: 17197850	2007
Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice. AJR. American journal of roentgenology\| PubMed ID: 17377054	2007
Transient global cerebral ischemia induces a massive increase in protein sumoylation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 17565359	2008
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 18167501	2008
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? Journal of neurochemistry\| PubMed ID: 18410505	2008
Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives. Experimental neurology\| PubMed ID: 18625221	2008
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free radical biology & medicine\| PubMed ID: 19631268	2009
Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage. Journal of neurosurgical anesthesiology\| PubMed ID: 19955895	2009
Development of a simplified spinal cord ischemia model in mice. Journal of neuroscience methods\| PubMed ID: 20394775	2010
Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass. Anesthesia and analgesia\| PubMed ID: 20519424	2010
Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. Stroke; a journal of cerebral circulation\| PubMed ID: 21193749	2011
The effect of blood pressure on cerebral outcome in a rat model of cerebral air embolism during cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 21277590	2011
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(II... Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 21384047	2011
Neuroprotective efficacy from a lipophilic redox-modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: rodent models of ischemic stroke and subarachnoid hemorrhage. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 21652782	2011
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Journal of proteome research\| PubMed ID: 22082260	2012
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. Free radical biology & medicine\| PubMed ID: 22336516	2012
Lack of evidence for a remote effect of renal ischemia/reperfusion acute kidney injury on outcome from temporary focal cerebral ischemia in the rat. Journal of cardiothoracic and vascular anesthesia\| PubMed ID: 22841525	2013
Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. Medical principles and practice : international journal of the Kuwait University, Health Science Centre\| PubMed ID: 23075911	2013
Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology\| PubMed ID: 23143806	2012
Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. Free radical biology & medicine\| PubMed ID: 23328731	2013
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature\| PubMed ID: 23615612	2013
Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. Inorganic chemistry\| PubMed ID: 23646875	2013
Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders. Antioxidants & redox signaling\| PubMed ID: 23706004	2014
Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 24301296	2014
Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways. Stroke; a journal of cerebral circulation\| PubMed ID: 24569813	2014
ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury. Journal of neuroscience research\| PubMed ID: 24633884	2014
Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories. Journal of psychiatry & neuroscience : JPN\| PubMed ID: 24690371	2014
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 11425886	2001
A blinded randomized assessment of laser Doppler flowmetry efficacy in standardizing outcome from intraluminal filament MCAO in the rat. Journal of neuroscience methods\| PubMed ID: 25526908	2015
Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25712497	2015
CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery. Neuroscience letters\| PubMed ID: 25881484	2015
Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model. International journal of radiation oncology, biology, physics\| PubMed ID: 26530759	2015
O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26661187	2016
Video training and certification program improves reliability of postischemic neurologic deficit measurement in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26661238	2016
Long-Term Cognitive Deficits After Subarachnoid Hemorrhage in Rats. Neurocritical care\| PubMed ID: 26896093	2016
Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 27217380	2017
Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume. The Journal of clinical investigation\| PubMed ID: 27400126	2016
Anesthesia in Experimental Stroke Research. Translational stroke research\| PubMed ID: 27534542	2016
Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. Neuroscience\| PubMed ID: 27919694	2017
Anesthetic Neuroprotection? It's Complicated. Anesthesiology\| PubMed ID: 28182586	2017
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. Stroke\| PubMed ID: 28487326	2017
Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 28505619	2017
Targeting the SUMO pathway for neuroprotection in brain ischaemia. Stroke and vascular neurology\| PubMed ID: 28959470	2016
Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice. Aging and disease\| PubMed ID: 29392079	2018
Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 29472640	2018
Novel Treatment of Cryptococcal Meningitis via Neurapheresis Therapy. The Journal of infectious diseases\| PubMed ID: 29788431	2018
High-speed widefield photoacoustic microscopy of small-animal hemodynamics. Biomedical optics express\| PubMed ID: 30319896	2018
Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice. Journal of the American Heart Association\| PubMed ID: 30371162	2018
Stroke Prevents Exercise-Induced Gains in Bone Microstructure But Not Composition in Mice. Journal of biomechanical engineering\| PubMed ID: 31596925	2019
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. Experimental neurology\| PubMed ID: 31962128	2020
PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis. Stroke\| PubMed ID: 32212900	2020
Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 32787543	2021
MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation. Journal of neuroinflammation\| PubMed ID: 32867797	2020
Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32910521	2020
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke. Experimental neurology\| PubMed ID: 33600817	2021
Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation. Journal of the American Heart Association\| PubMed ID: 34013738	2021
Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice. Journal of the American Heart Association\| PubMed ID: 34111943	2021
Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice. Shock (Augusta, Ga.)\| PubMed ID: 34652341	2021
Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy. Neuromodulation : journal of the International Neuromodulation Society\| PubMed ID: 35131154	2022
Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice. Brain research bulletin\| PubMed ID: 35304288	2022
Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice. Oxidative medicine and cellular longevity\| PubMed ID: 35391930	2022
Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke. Journal of neuroinflammation\| PubMed ID: 35392936	2022
Myocardial Injury Caused by Chronic Alcohol Exposure-A Pilot Study Based on Proteomics. Molecules (Basel, Switzerland)\| PubMed ID: 35807529	2022
Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats. Biology\| PubMed ID: 36101338	2022
SIRT1 Activation Promotes Long-Term Functional Recovery After Subarachnoid Hemorrhage in Rats. Neurocritical care\| PubMed ID: 36224490	2022
Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke. Frontiers in cellular neuroscience\| PubMed ID: 36313623	2022
A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis. Science immunology\| PubMed ID: 36930731	2023
Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage. Neuroendocrinology\| PubMed ID: 26562172	2016
Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome. Critical care medicine\| PubMed ID: 31094741	2019
Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (HO)MnTnHex... Antioxidants (Basel, Switzerland)\| PubMed ID: 32492872	2020
Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside. Journal of biophotonics\| PubMed ID: 33768709	2021
HO-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. Oxidative medicine and cellular longevity\| PubMed ID: 33815656	2021
Real-time whole-brain imaging of hemodynamics and oxygenation at micro-vessel resolution with ultrafast wide-field photoacoustic microscopy. Light, science & applications\| PubMed ID: 35577780	2022
Deep-tissue SWIR imaging using rationally designed small red-shifted near-infrared fluorescent protein. Nature methods\| PubMed ID: 36456785	2023
Author Correction: Deep-tissue SWIR imaging using rationally designed small red-shifted near-infrared fluorescent protein. Nature methods\| PubMed ID: 36725988	2023
Epinephrine-induced effects on cerebral microcirculation and oxygenation dynamics using multimodal monitoring and functional photoacoustic microscopy. Anesthesiology\| PubMed ID: 37079748	2023
Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP, following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats. Antioxidants (Basel, Switzerland)\| PubMed ID: 37891940	2023
Multi-molecular hyperspectral PRM-SRS microscopy. Nature communications\| PubMed ID: 38383552	2024
Microglial heterogeneity in the ischemic stroke mouse brain of both sexes. Genome medicine\| PubMed ID: 39095897	2024
Data analysis protocol for early autonomic dysfunction characterization after severe traumatic brain injury. Frontiers in neurology\| PubMed ID: 39777307	2024
Glucocorticoid signaling mediates lymphopoiesis impairment after cardiac arrest in mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 39835422	2025
Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction. Journal of clinical medicine\| PubMed ID: 39860563	2025
Ischemic stroke reduces bone perfusion and alters osteovascular structure. Bone reports\| PubMed ID: 39896107	2025
Activation of ATF6 Signaling Confers Long-Term Beneficial Effects in Young and Aged Mice After Permanent Stroke. Translational stroke research\| PubMed ID: 40259100	2025
Treatment with Manganese Porphyrin, MnTnBuOE-2-PyP, Suppressed the Activation of Macrophages in a Mouse Intracerebral Hemorrhage. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 40283982	2025
Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout. Nature communications\| PubMed ID: 40659617	2025
Activation of intestinal mast cells contributes to gut damage after cardiac arrest in mice. Shock (Augusta, Ga.)\| PubMed ID: 40663478	2025
SUMOylation Regulates Neutrophil Phagocytosis and Migration. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 40732357	2025
Suppression of Paclitaxel-Induced Neuropathy and Ovarian Tumor Growth by Mn Porphyrin, MnTnBuOE-2-PyP (BMX-001). Oxidative medicine and cellular longevity\| PubMed ID: 40900760	2025